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Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Certain natural compounds can block an enzyme linked to prostate enlargement and hair loss, showing potential for new treatments.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

A new compound from a sponge strongly inhibits an enzyme linked to male-pattern hair loss without being toxic at low levels.

4-(4-Phenoxybenzoyl)benzoic acid derivatives can both increase and decrease certain types of reactive oxygen species, and may be relevant to hair loss.

Dutasteride is more efficient than finasteride, but individual results vary.

Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.

Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

Finasteride works better than Permixon in reducing dihydrotestosterone levels.

Some Thai plants, especially Carthamus tinctorius, could help prevent hair loss and promote hair growth without adverse effects.

Finasteride doesn't harm bone density in older men with BPH.

Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.

Finasteride and minoxidil together promote hair growth better than either alone.

Eclipta alba extract could be a promising natural treatment for hair loss.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Bee venom helps hair grow and may work better than some common treatments.

Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.