Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study reports that hair follicles can mobilize ectopic progenitors for regeneration to repair damage from ionizing radiation. Augmenting WNT signaling enhanced this regenerative process and prevented radiation- and chemotherapy-induced hair loss, highlighting a potential approach to manage alopecia during cancer treatment.

This study demonstrated that an engineered human skin equivalent can generate follicle-like structures resembling fetal skin, highlighting the role of the dermal compartment in directing epithelial cell fate in vitro.

This research reports that after genotoxic stress from ionizing radiation or chemotherapy, hair follicles can utilize progenitor cells from transit-amplifying compartments, not quiescent stem cells, for repair, suggesting a potential therapeutic approach to prevent therapy-induced hair loss by activating these progenitors.

In this study, various cellular responses and signaling pathways were examined in hair follicles after exposure to ionizing radiation, including the effects of Wnt3a treatment, with findings noted in apoptosis, DNA damage, and differentiation processes.

Results are not reported in this study, which investigated the effects of radiation on hair follicles and evaluated various cellular responses and signaling pathways, particularly focusing on WNT signaling and the impact of Wnt3a treatment.

This study found that cow placenta extract increased hair follicle size and hair length in mice but was less effective than minoxidil, suggesting potential with further refinement.

This study suggests that IGFBP-2 may play a role in basal cell carcinoma development by mediating epidermal progenitor cell expansion in hair follicles with activated Shh signaling.

This study suggests that porphyra-334 may have antiaging properties, promoting collagen synthesis, improving periorbital wrinkles, and supporting hair follicle growth through gene regulation.

In a study using a rat model, researchers developed injectable hydrogels from antler reserve mesenchyme which enhanced regenerative healing of full-thickness cutaneous wounds by creating a fetal-like niche that increased stem cell presence and modulated gene expression related to wound healing.

This perspective discusses Villani et al.'s findings on the role of the IGF regulatory protein Igfbp2 in basal cell carcinogenesis and highlights potential therapeutic and preventive targets, while raising questions about the cell of origin.

This study found that ILC1-like cells can induce alopecia areata in healthy human hair follicles, challenging the traditional belief that the disease is primarily driven by CD8+ T cells.

This study found that keratinocyte stem/progenitor cell-conditioned medium significantly enhanced hair growth in mice and increased the proliferation of human hair follicle cells.

Female-pattern hair loss may involve an autoimmune-like process, suggesting new treatment options.

This study found that toll-like receptor 9 plays a previously unrecognized role in sensing skin injury and influencing tissue repair and regeneration in adult mice by modulating γδT cell migration.

PPAR-γ agonists like pioglitazone may help manage lichen planopilaris but don't fully reverse scarring.

This study found that abnormal Wnt signalling in stem cells may contribute to blackhead formation in acne by inhibiting cell differentiation and causing cell accumulation in the junctional zone.

This study found that 5-aminolevulinic acid combined with ferric ammonium citrate stimulated hair follicle growth and induced hair-like structures in human hair follicle models, suggesting its potential as a treatment for hair loss.

In this study, researchers developed a multilayered gel bead culture model using a microgel-spotting device, successfully mimicking the early development of skin appendages and supporting in vitro hair follicle regeneration with structures resembling native hair follicles.

This study suggests that allergens like linalool found in personal care products may contribute to the pathobiology of frontal fibrosing alopecia by affecting immune responses and stem cell function in hair follicles.

This review discusses circadian clock regulation in stem cells and its role in processes like neurogenesis, but reports no new results; the authors emphasize its significance in stem cell function across various tissues.

This review discusses how inflammation influences hair follicle stem cell activities like wound healing and follicle cycling and suggests a potential link between inflammation, stem cell activation, and programmed cell death.

The document concludes that both internal stem cell factors and external influences like the environment and hormones affect hair loss and aging, with potential treatments focusing on these areas.

This review discusses current and potential approaches using stem cells for treating hypopigmentation disorders like vitiligo but does not present new clinical findings.

This review highlights that stem cell-based therapies show promise in skin regeneration for conditions like chronic wounds and burns due to their regenerative and immunomodulatory effects, though challenges like safety and scalability limit widespread clinical use.

This study critically reviewed recent evidence (2020–2025) on treatments like platelet-rich plasma, photobiomodulation, stem cells, and exosomes for androgenetic alopecia, finding emerging but limited efficacy data and emphasizing the need for standardized protocols to enhance transparency and patient safety.

This study showed that exosomes from hyaluronic acid-primed induced mesenchymal stem cells promote hair growth by enhancing proliferation and migration of hair follicle dermal papilla cells and modulating key growth factors and signaling pathways, potentially counteracting the effects of DHT-induced hair loss.

Blocking a compound called prostaglandin D₂ might help treat hair loss.

This study found that exosomes from hyaluronic acid-primed mesenchymal stem cells may promote hair growth in androgenetic alopecia by improving hair follicle cell function and restoring key signaling pathways disrupted by DHT.

This study found that nestin-expressing cells in the hair follicle bulge exhibit multipotent stem cell-like properties and can generate neural cells both in vitro and in vivo.

This study identified highly variable genes in mesenchymal stem/stromal cells that are linked to classic functions like development and inflammation response, suggesting their potential as markers for further potency studies.