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Deregulation of stem cell function is central to the development of some cancers.

Stem cells can help other stem cells by producing supportive factors.

Inactive stem cells in hair follicles and muscles can avoid detection by the immune system.

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

Male hair loss is caused by inactive hair follicle stem cells.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

Using stem cells from fat tissue can significantly improve wound healing in dogs.

GPR39 is linked to certain cells in the sebaceous gland and helps with skin healing.

Hair growth environment recreated with challenges; stem cells make successful skin organoids.

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

The document concludes that while some organisms can regenerate body parts, mammals generally cannot, and cancer progression is complex, involving mutations rather than a strict stem cell hierarchy.

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

Escin may help treat hair loss by boosting a specific cell growth pathway.

Androgens affect bone and fat cell development differently based on the cells' embryonic origin.

The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.

Hair follicles are essential for skin health, aiding in hair growth, wound healing, and immune function.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Aging slows wound healing due to weaker cells and immune response.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Activating Notch signaling can kill basal cell carcinoma cells.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

New biofabrication technologies could lead to treatments for hair loss.

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.

Krt15+ cells in the mouse intestine resist radiation and can start tumors.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.

Increasing Rps14 helps grow more inner ear cells and repair hearing cells in baby mice.

Testosterone helps beard and axillary hair cells grow by releasing growth factors from dermal papilla cells.