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The skin's dermal layer contains true stem cells with diverse functions and interactions that need more research to fully understand.

Stem cell niches support, regulate, and coordinate stem cell functions.

Some stem cells in the body rarely divide, which could help create better treatments for diseases and aging.

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

Epidermal stem cells have various roles in skin beyond just maintenance, including forming specialized structures and aiding in skin repair and regeneration.

Epidermal stem cells create and maintain skin structures like hair and nails through specific signaling pathways and vary by location and function.

Sebaceous glands can heal and regenerate after injury using their own stem cells and help from hair follicle cells.

ASH2L is essential for skin and hair development.

Stress turns hair white by depleting color-giving cells in hair follicles through a specific neurotransmitter related to the body's stress response.

WWOX deficiency in mice causes skin and fat tissue problems due to disrupted cell survival signals.

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.

Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.

Stem cell niches are adaptable and key for tissue maintenance and repair.

The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.

Hair and skin can regenerate without bulge stem cells due to other compensating cells.

Collagen XVII is important for skin aging and wound healing.

Newly found stem cells in horse hooves show promise for treating a hoof disease called laminitis.

Eating fewer calories improves the ability of stem cells to repair and renew the body in various tissues.

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

Different types of stem cells and their environments are key to skin repair and maintenance.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

Low-dose radiation affects hair stem cell function and survival by changing their genetic material's structure.

New methods have greatly improved our understanding of stem cell behavior and roles in the body.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Intravital imaging helps us better understand stem cells in their natural environment and could improve knowledge of organ regeneration and cancer development.