12 citations
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August 2018 in “Journal of Dermatological Science” This study observed that adipose-derived stem cells modified with trichogenic factors have similar properties to dermal papilla cells and show enhanced hair regeneration potential compared to unmodified adipose-derived stem cells.
9 citations
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June 2017 in “PubMed” This review discusses the potential of stem cell therapy for hair regrowth, emphasizing the advantages and promising outcomes, but reports no new clinical results.
4 citations
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February 2022 in “JAAD case reports” This case report describes a patient with permanent chemotherapy-induced alopecia who experienced full hair regrowth after treatment with low-dose oral minoxidil.
1 citations
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August 2019 in “Chinese Medical Journal” This case report describes a 43-year-old man who developed lupus miliaris disseminatus faciei after discontinuation of cyclosporine A post-stem cell transplantation, successfully treated with oral isotretinoin and topical tacrolimus.
January 2026 in “Plastic & Reconstructive Surgery Global Open” This study reported that applying stem cell serum daily resulted in eyebrow hair regrowth in a patient with chronic secondary cicatricial alopecia, and prevented hair loss in another patient with acute eyebrow trauma, suggesting it as a noninvasive treatment alternative.
December 2025 in “International Journal for Fundamental and Interdisciplinary Research in Homoeopathy.” In this case study, a 37-year-old man with chronic hair loss and vertex baldness experienced significant hair regrowth, increased density, and improved appearance after receiving combined homoeopathic and aesthetic treatments, resulting in nearly complete coverage of bald areas.
September 2024 in “British journal of surgery” In this study, autologous stem cell therapy was associated with a 29% increase in hair density in androgenetic alopecia patients over six months, suggesting potential for further investigation.
July 2024 in “British journal of surgery” This review reports that regenerative medicine, such as autologous stem cell micrografting and Rigenera®, may significantly improve hair density in individuals with androgenetic alopecia, highlighting its potential as a future therapeutic option that addresses current treatment limitations.
June 2024 in “Skin Appendage Disorders” In this study, injections of PRP and MZT products significantly improved hair thickness, density, and count in AGA patients over six months, with variability observed in the extent of improvement between different formulations.
August 2023 in “Stem Cell Research & Therapy” In this study on male androgenetic alopecia, the researchers reported significant increases in hair count, density, and thickness with minimal side effects over 6 weeks using adipose-derived stem cell conditioned media and minoxidil, but found no significant differences between concentrated and non-concentrated treatments.
June 2009 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that Lrig1-positive cells in mouse epidermis are a previously unidentified source of adult interfollicular epidermal stem cells, which can contribute to sebaceous gland and epidermal lineage formation.
This review suggests that stem cells might be a promising addition or alternative to standard treatments for androgenic alopecia, but larger studies are needed to confirm these findings.
91 citations
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March 2011 in “Stem Cell Reviews and Reports” This article describes protocols for isolating and expanding human epidermal neural crest stem cells and discusses their potential for cell-based therapies in regenerative medicine, but reports no new clinical results.
84 citations
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January 2008 in “Cold Spring Harbor Symposia on Quantitative Biology” This article reviews recent advancements in understanding skin stem cells and their roles in maintaining epidermal homeostasis and repairing wounds, without presenting new experimental findings.
21 citations
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October 2009 in “Biochemical Engineering Journal” This review discusses various approaches to treating alopecia, including drug therapy and hair transplantation, but reports no new research findings; the authors highlight the need for novel techniques like cell culturing.
This review discusses the roles and characteristics of skin stem cells, their niches, and signaling pathways in skin maintenance, aging, and cancer, highlighting their potential in therapeutic applications but presenting no new clinical findings.
January 2026 in “International Journal of Molecular Sciences” In this study, researchers identified S100a4 as a critical regulator of secondary hair follicle stem cells in cashmere goats, linking its expression to follicle regeneration and differentiation pathways, which may have implications for enhancing cashmere fiber production.
18 citations
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November 2013 in “Molecules and Cells” This study found that a novel 3D in vitro culture condition improved stemness markers and proliferation potential in human dermal stem/progenitor cells compared to traditional 2D methods.
11 citations
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June 2021 in “Frontiers in Cell and Developmental Biology” This study found that melatonin may enhance goat cashmere growth by activating Wnt signaling and regulating stem cell pluripotency through mechanisms involving NOGGIN and BMP4 pathways.
10 citations
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January 2013 in “Stem Cells and Development” This study suggests that dermal stem/progenitor cells can be enriched by intracellular granularity and display high proliferation and differentiation potential in vitro, distinguishing them from other fibroblasts and progenitors.
503 citations
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May 2009 in “Cell stem cell” This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.
396 citations
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May 2011 in “Cell stem cell” This study found that Shh from neurons signals to Gli1-expressing cells in the hair follicle, cultivating a niche where these bulge cells can potentially transform into epidermal stem cells in wound healing.
333 citations
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February 2010 in “Cell Stem Cell” This review discusses experimental data, technologies, and genetic factors related to stem cell niches, highlighting their role in tissue regeneration and diseases, but reports no new results.
214 citations
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April 2017 in “Cell” This study found that micro-niches within hair follicles create heterogeneity among stem cells and transit-amplifying cells, leading to specialized progenitors that control tissue morphogenesis and regeneration.
211 citations
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May 2018 in “Trends in cell biology” This review explores recent insights into the diverse cell populations involved in skin development, homeostasis, wound healing, and cancer progression but reports no new results.
209 citations
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October 2008 in “The Journal of Pathology” This review discusses the niches supporting adult stem cells in various organisms, including well-studied germline niches and the less understood mammalian niches, but it reports no new research findings.
176 citations
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January 2013 in “Proceedings of the National Academy of Sciences” This study reveals an antagonistic competition between BMP and Wnt signaling within stem cells, influencing their fate towards hair germ characteristics based on the BMP/Wnt activity ratio.
149 citations
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July 2014 in “Cold Spring Harbor Perspectives in Medicine” This article provides contact information for Bruce A. Morgan and features no new research findings.
143 citations
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May 2017 in “Nature cell biology” This study found that the transcription factor Gata6 regulates the sebaceous duct lineage identity and plays a crucial role in epidermal wound healing by enabling dedifferentiation and broader lineage capabilities in post-mitotic cells.
116 citations
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April 2020 in “Stem Cell Research & Therapy” This study identified highly variable genes in mesenchymal stem/stromal cells that are linked to classic functions like development and inflammation response, suggesting their potential as markers for further potency studies.