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Healthy aging can be promoted through physical activity, lifestyle changes, and certain treatments.

This study found that young host mice rejuvenated aged hair follicles after transplantation, while aged host mice did not support hair growth from transplanted follicles.

This review discusses manipulating the stem cell niche as a strategy in regenerative medicine to repair damaged tissues, highlighting the potential benefits and challenges but reporting no new results.

In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.

This study found that stem cell therapy significantly improved burn healing rates in animal models, with hair follicle stem cells showing particularly strong effects.

This review discusses the paracrine properties of cardiac stem cells and pericytes in regenerative medicine for ischaemic diseases and reports no new clinical results.

This review discusses the impact of calorie restriction on enhancing stem cell potency and regenerative abilities in mammalian tissues and reports no new experimental results.

In this phase I/II clinical trial, placenta-derived mesenchymal stem cell exosome therapy significantly improved hair density and diameter, and reduced hair loss in patients with androgenetic alopecia, though further large-scale studies are needed to confirm these results and investigate the underlying molecular mechanisms.

This review discusses the distinction between platelet-rich plasma and stem cell-based therapies in regenerative medicine, highlighting their different roles and stressing the importance of honest representation by commercial and health entities.

This study found that the majority of UK clinics market stem cell treatments ethically questionably, often omitting risk information, exaggerating effectiveness, and using celebrity testimonials.

This forum article in BMC Biology discusses evolving views on the concept of the stem cell niche, highlighting varied mechanisms and the need for better understanding of the niche's roles and functions.

This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.

This review discusses the potential of stem cell secretome in regenerative medicine and suggests that its paracrine effects, rather than direct cell replacement, may drive therapeutic benefits.

This review addresses the role of skin-resident adult stem/progenitor cells in skin homeostasis, disease, and cancer development, and reports no new research results.

This study found that intradermal administration of adipose-derived stem cell–conditioned medium significantly increased hair density and dermal thickness, suggesting potential regenerative effects on both hair follicles and the interfollicular scalp in patients with alopecia.

This article explores questions about dormant hematopoietic stem cells and suggests avenues for future research, but does not present new experimental results.

This review examines how caloric restriction could promote autophagy to rejuvenate aging stem cells, though the precise molecular mechanisms remain unclear.

In this study, mesenchymal stem cell-conditioned medium gel significantly improved wound healing and accelerated hair growth in rats with third-degree burns compared to a placebo, silver sulfadiazine, or no treatment.

This review highlights the promising role of stem cell therapy in treating resistant diseases, while also addressing the challenges in production and clinical application, emphasizing the need for standardized manufacturing and quality assurance to enhance efficacy and safety in clinical translational research.

This narrative review highlights the potential of autologous adipose mesenchymal stem cell-derived exosomes (AMSCs-Exos) in anti-skin aging, noting their superior biocompatibility and manufacturing advantages while stressing the need for standardized production protocols to overcome existing application challenges.

This review summarizes discussions from a 2010 stem cell biology meeting, covering the origin, behavior, and therapeutic potential of pluripotent and multipotent stem cells, without reporting new experimental findings.

This study suggests that the activation of box A in mesenchymal cell models may enhance stem cell properties, increasing the expression of stemness markers like OCT4, NANOG, and SOX2.

At the 21st Royan International Stem Cell Congress, researchers highlighted the growing integration in regenerative medicine, emphasizing advances in pluripotency, AI applications, and bioengineering for the development of accessible stem cell therapies.

In this study, researchers suggest that hair follicle miniaturization in conditions like androgenetic alopecia may result from impaired conversion of quiescent stem cells to progenitor cells, influenced by the follicular niche, its collagen network, and various mechanical constraints.

This study found that exosomes derived from hypoxia-conditioned mesenchymal stem cells modulated inflammatory biomarkers by decreasing CXCL12 and increasing IL-10 expression in a DHT-induced androgenic alopecia mouse model, indicating potential for treating hair loss through immunoregulation.

In this review study, researchers examined existing literature on regenerative medicine and stem cells for androgenetic alopecia and highlighted potential new therapeutic techniques for hair regrowth, emphasizing stem cells' impact on prognosis.

This randomized control trial reported that mesenchymal stem cell-derived exosomes significantly increased hair density and thickness in patients with androgenic alopecia, with a mean increase of 35 hairs/cm² over 12 weeks compared to the placebo group, which showed minimal hair density changes.

This study reviews the potential of stem cell-based therapies, including transplants and exosome treatments, to reactivate hair follicle stem cells and promote hair growth in individuals experiencing pattern hair loss.

This study suggests that using cell-free dexamethasone-primed stem cell media may offer a promising alternative treatment for systemic lupus erythematosus, showing immunomodulatory benefits and therapeutic efficacy in reducing various complications.

This study found that disrupted cholesterol homeostasis impairs hair regrowth in individuals with primary cicatricial alopecia by damaging hair follicle stem cells, highlighting the importance of cholesterol in maintaining stem cell function and hair follicle integrity.