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    Glossary Stem Cell Function

    ability to self-renew and become specialized cell types

    Stem cell function refers to the ability of stem cells to self-renew and differentiate into various specialized cell types. This means they can both replicate themselves to maintain the stem cell pool and transform into different types of cells needed for growth, repair, and maintenance of tissues, including hair follicles. This dual capability is crucial for regenerative medicine and understanding conditions like alopecia, where hair growth is disrupted.

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    1. Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions PLOS ONE · 2011 · 61 citations
    2. Stem Cell Secretome for Skincare: Of Cell Types, Exosomes, Extracellular Vesicles, and Soluble Fractions Preprints.org · 2025
    3. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    4. Function of KLF4 in Stem Cell Biology InTech eBooks · 2013 · 5 citations
    5. Fully functional hair follicle organ regeneration using organ-inductive potential stem cells with an accessory mesenchymal cell population in an in vitro culture system Biochemical and Biophysical Research Communications · 2026
    6. 22 Biological functions of exosome-like nanoparticles isolated from rose (rosa damascena) stem cell culture (RSCE) 2023
    7. Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies Journal of Cellular and Molecular Medicine · 2009 · 36 citations
    8. Hair, Cutaneous Homeostasis and Stem Cell Functions Journal of Investigative Dermatology · 2014
    9. The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function EMBO Reports · 2021 · 10 citations
    10. State-dependent signaling by Ca<sub>v</sub>1.2 regulates hair follicle stem cell function Genes & development · 2013 · 27 citations
    11. Research Progress on Targeted Regulation of Hair Follicle Stem Cell Function in the Treatment of Androgenetic Alopecia Pharmacy information · 2024
    12. Functional stem-cell based tissue engineered vascular grafts for high-risk donor populations D-Scholarship@Pitt (University of Pittsburgh) · 2015
    13. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    14. The dual role of stem cell-specific Bcl-2 function for epidermal regeneration and cancer 2019
    15. Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration Journal of Biomedical Science · 2020 · 59 citations
    16. Regulation of stem cell function by protein ubiquitylation EMBO Reports · 2014 · 55 citations
    17. Fibrous scaffolds potentiate the paracrine function of mesenchymal stem cells: A new dimension in cell-material interaction Biomaterials · 2017 · 182 citations
    18. Vitamin D receptor is essential for normal keratinocyte stem cell function Proceedings of the National Academy of Sciences · 2007 · 143 citations
    19. A regenerative stem cell-derived matrix accelerates functional dermal wound repair in a preclinical diabetic model 2026
    20. Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity Nature Reviews Molecular Cell Biology · 2023 · 200 citations
    21. Distinctive T Cell Patterns Defining Lymphocytic Alopecia and Alternate Autoimmune and Stem Cell Pathways, Linked to Pleiotropic Functions of Regulatory T Cells Within iSALT American Journal of Dermatopathology · 2026
    22. Age-associated inflammation inhibits epidermal stem cell function Genes & development · 2012 · 144 citations
    23. 1372 Modulation of YBX1 phosphorylation determines epidermal stem cell function Journal of Investigative Dermatology · 2023
    24. Signaling in the stem cell niche: regulating cell fate, function and plasticity Development · 2018 · 139 citations
    25. Functional endoscopy techniques for tracking stem cell fate Quantitative Imaging in Medicine and Surgery · 2019 · 5 citations
    26. The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function Oncogene · 2022 · 3 citations
    27. N1-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles Archives of dermatological research · 2015 · 13 citations
    28. Poster 149 Rehabilitation, Functional Status Relationship to Re‐hospitalization Rates in Patients with Hematologic Malignancy after Hematopoietic Stem Cell Transplant PM&R · 2014
    29. 19 Adipose stem cell exosome (ASCE): next generation regenerative therapeutics for atopic dermatitis Journal of Investigative Dermatology · 2023
    30. The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate Trends in cell biology · 2018 · 33 citations