6 citations
,
December 2011 in “Nature” This study found that the circadian clock regulates the activation and heterogeneity of hair follicle bulge stem cells, affecting tissue homeostasis and tumorigenesis risk in mouse skin.
November 2014 in “Journal of Cell Biology” Valentina Greco's research shows that the environment around hair follicle stem cells is more crucial for regeneration than the stem cells themselves.
260 citations
,
June 2011 in “Cell” This study found that Wnt signaling in the hair follicle is crucial for coordinating the behavior of epithelial and melanocyte stem cells, which drives hair regeneration and melanocyte differentiation in mice.
180 citations
,
January 2011 in “EMBO Reports” This review discusses strategies for identifying and characterizing adult stem cells in mice and highlights their potential and limitations, but reports no new experimental results.
164 citations
,
February 2010 in “Journal of Cell Science” This study demonstrates that stem cells from human foreskins, which lack hair follicles, can differentiate into melanocytes and migrate to the epidermis, potentially altering our understanding of pigmentation disorders.
43 citations
,
August 2018 in “Cell Stem Cell” This study found that Hoxc gene expression can reprogram mesenchymal dermal papilla cells, enhance epithelial stem cell regenerative potential, and promote region-specific hair follicle regeneration through Wnt signaling.
5 citations
,
May 2020 in “Wiley Interdisciplinary Reviews Developmental Biology” This article reviews the mechanisms controlling long bone growth and suggests that new research approaches are needed to explore the role of extrinsic signals and tissue interactions.
86 citations
,
February 2012 in “Journal of Clinical Investigation” This review discusses recent advances in understanding hair follicle stem cell dynamics and interactions, but it reports no new experimental findings.
18 citations
,
February 2022 in “Cell Death Discovery” In this study, researchers found that hair follicle-derived mesenchymal stem cells, modified to overexpress extracellular matrix protein 1, significantly improved liver function and reduced liver damage in cirrhotic mice by inhibiting hepatic stellate cell activation and TGF-β/Smad signaling.
33 citations
,
October 2013 in “PloS one” This study found that human sweat glands contain unique stem cells with significant multilineage differentiation potential and self-renewal abilities, suggesting promising clinical applications due to easy biopsy access.
March 2014 in “Anais Brasileiros de Dermatologia” This review describes the hair follicle's structure, particularly its role as a stem cell niche, and discusses its potential application in skin tissue engineering, but does not present new research findings.
12 citations
,
October 2023 in “International Journal of Molecular Sciences” This review examined the pathological effects of mechanical pressure on human skin at the cellular level, highlighting how various skin cell types respond to pressure, potentially leading to pathological changes such as inflammation, ischemia, and impaired differentiation.
2 citations
,
November 2023 in “Laboratory Animal Research” In this study, the combination of conditioned medium from human adipose-derived stem cells and photobiomodulation significantly enhanced wound healing in type 2 diabetic rats compared to using either treatment alone, with particularly superior results in wound strength and new blood vessel formation.
May 2024 in “Archives of Dermatological Research” TAT-GILZ peptide promotes hair growth by boosting stem cell activity.
48 citations
,
July 2008 in “Acta Biochimica et Biophysica Sinica” This review discusses the roles and mechanisms of Wnt signaling in embryonic and adult stem cells and its association with cancers, and reports no new experimental findings.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that while niche architecture optimizes organ efficiency during hair follicle growth, it is not essential for the function of stem cell-derived tissues.
This study successfully established a functionally stable immortalized sheep granulosa cell line (GCs-SV40T-GFP) that can passaged up to 50 generations, maintaining morphological stability and estradiol secretion, offering a valuable model for research into animal reproductive function and hormone regulation.
1 citations
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January 2016 in “Elsevier eBooks” This chapter discusses the composition, biocompatibility, and production methods of biomaterials like collagen, chitin, and silk for dermal substitutes, focusing on preclinical and clinical research, but reports no new clinical results.
This review discusses the use of umbilical cord blood in regenerative medicine, focusing on collection, banking processes, and ethical considerations, without presenting new clinical results.
417 citations
,
September 2005 in “PLoS biology” This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.
45 citations
,
October 2018 in “JCI Insight” In a preclinical mouse model, this study found that early treatment with the selective SYK inhibitor entospletinib significantly improved survival rates and clinical outcomes for graft-versus-host disease after hematopoietic stem cell transplantation compared to placebo.
18 citations
,
August 2015 in “International Journal of Molecular Sciences” This study developed an efficient method for isolating and enriching multipotent ovine hair follicle stem cells, which may aid in research on the ovine hair cycle and future wool production.
2 citations
,
May 2021 in “Stem Cells International” This study reviewed the progress in developing induced platelets from human stem cells as an alternative source to meet clinical demands, although challenges remain for large-scale production and clinical application.
479 citations
,
June 2014 in “Science” This review discusses the plasticity of epithelial stem cells in regenerative contexts and reports no new research findings; the authors highlight potential implications for regenerative medicine and cancer.
7 citations
,
July 2012 in “Regenerative Medicine” This article summarizes recent highlights in regenerative medicine research but reports no new experimental findings.
387 citations
,
May 2019 in “International Journal of Molecular Sciences” This review discusses the therapeutic potential of adipose-derived stem cells compared to other mesenchymal stem cells, emphasizing their promise in treating neurodegenerative, cardiovascular, and autoimmune diseases, but reports no new clinical results.
421 citations
,
January 2015 in “Chemical Society Reviews” This review discusses recent advances in surface modification and endothelialization of biomaterials for vascular grafts, highlighting promising methods like gene engineering and targeting ligand immobilization to improve clinical outcomes.
306 citations
,
April 2019 in “International Journal of Molecular Sciences” This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.
39 citations
,
April 2019 in “Journal of Biomaterials Science, Polymer Edition” This review discusses recent research and applications of RADA16 and RADA16-based peptide scaffolds in biomedicine, including their roles in tissue repair and drug delivery, but reports no new clinical results.
17 citations
,
January 2013 in “Journal of Cosmetics, Dermatological Sciences and Applications” This review discusses the potential of bioprinting technology in cosmetology, particularly for improving skin functions like pigmentation restoration and hair follicle development, but reports no new clinical findings.