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This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.

This review examines the potential and challenges of extracellular vesicles in cosmetics, noting their transformative impact despite regulatory and production hurdles; it reports no new experimental results.

This study found that murine vibrissa hair follicle stem cells can be differentiated into corneal epithelial-like cells in vitro using limbus-specific microenvironmental factors, suggesting a potential therapeutic source for ocular surface disorders.

Mesenchymal stromal cell therapies show promise for treating various diseases but need more research and standardization.

This study developed HA-gel-dex hydrogels with enhanced ECM-like properties and functionality, showing promise for 3D bioprinting, tissue repair, and as wound dressings due to improved cell interaction, cytocompatibility, antimicrobial synergy, and wound healing in mice compared to traditional ECM bio-inks.

Discoid lupus erythematosus involves immune activation and fibrosis around hair follicles, with shared pathways across humans, dogs, and mice, suggesting potential treatments for both humans and animals.

In this multicenter observational study, researchers found that using micrografts with human follicle mesenchymal stem cells increased hair density significantly in both male and female patients with mild to moderate androgenic alopecia after 12 months, suggesting a viable alternative for hair regrowth.

This study found that injections of extracellular vesicles derived from mesenchymal stem cells improved hair growth in over 50% of female and nearly 80% of male patients after six months.

This paper discusses the potential roles of adipose tissue derived stem cells in skin regeneration and wound healing but emphasizes the need for further research on their effectiveness in clinical settings.

This study found that neural stem cell extract enhanced hair growth in mice and cells by stimulating hair follicle niches and activating signaling pathways like TGF-β and BMP.

This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.

This study found that mesenchymal stem cells derived from dental pulp and adipose tissue have distinct gene expression signatures that suggest potential target diseases for clinical applications.

In this study, upper-bulge epidermal stem cells in mouse hair follicles were shown to play a role in forming tactile sensory units by creating an extracellular matrix that supports nerve interactions.

This study found that generating pluripotent stem cell-derived skin organoids in a 3D bioprinted hydrogel device improved keratinocyte differentiation and hair follicle formation while reducing necrosis.

Reducing neutrophils or inhibiting NETs improves wound healing in sickle cell disease.

In this study, treatment with cell-derived nanovesicles from hair follicle mesenchymal stem cells improved photoaging signs in UVB-exposed mice and human dermal fibroblasts by reducing oxidative stress, enhancing cell proliferation, and promoting extracellular matrix production.

This review highlights the potential of drug-loaded extracellular vesicles as a promising drug delivery platform but notes that clinical translation faces challenges due to variability in methods and the need for standardization and safety evaluation.

This study found that a novel ECM patch combining human fibroblast-derived matrix and PVA hydrogel, seeded with human mesenchymal stem cells, significantly improved wound healing and tissue regeneration in a mouse model.

In this study, exosome-mimetic nanovesicles derived from ReNcell VM cells promoted hair growth in mice by enhancing dermal papilla cell proliferation and activating the Wnt/β-catenin signaling pathway.

This study found that adipose‐derived stem cells can restore skin barrier function and inhibit photoaging-related responses in UVB-irradiated mice, suggesting a potential therapeutic role in managing skin photoaging.

This study explored the effects of USPlus® DERM, a bioactive fatty acid extract from Serenoa repens, in promoting hair growth and enhancing hair follicle stem cell stemness in an ex vivo setting, showing potential for both 5‐α reductase-dependent and independent hair loss treatments.

This review suggests that induced pluripotent stem cells (iPSCs) hold promise for treating chronic wounds, but further work is needed to address safety, efficacy, and translation from preclinical models to real-world applications.

In this study, tea tree oil was found to have substantial antibacterial activity and promote proliferation and migration of hair follicle stem cells in vitro, indicating potential benefits for treating scalp alopecia areata.

This article reviews treatment options for cutaneous T-cell lymphoma, including skin-directed therapies and aggressive treatments for advanced cases, but reports no new clinical results.

In this study, researchers reported that hair follicle stem cells maintain quiescence through a PIEZO1-dependent mechanism that senses mechanical forces and translates them into localized calcium influx, involving a transcriptional network that regulates cell adhesion and cytoskeleton-related genes.

This review discusses the potential of adipose-derived tissue components like nanofat and stem cells for aesthetic rejuvenation, covering their use in hair growth, scar reduction, and more, without reporting new clinical results.

This review discusses the therapeutic potential of mesenchymal stem cell-derived small extracellular vesicles for chronic wound treatment and reports no new clinical results, emphasizing the need for further research on their large-scale production and engineering.

HA-iMSC-EVs can improve skin aging by boosting cell growth and restoring collagen and elastin.

This review discusses the role of hair follicle stem cell metabolism, ageing, and microenvironment in hair growth disorders and compiles recent research on using stem cell-based regenerative medicine for treating alopecia, without reporting new clinical results.

This study discusses how redox imbalance, specifically through reduced Insulin-like Growth Factor-1 mediated by the transcription factor JunB and sphingolipid metabolism changes, contributes to skin aging by depleting stem cell pools and altering the extracellular matrix, ultimately impacting skin integrity and function.