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This study found that combining natural extracts significantly boosted the stem cell functions of dermal papilla cells by enhancing β-catenin stability, promoting hair growth potential in vitro.

This review discusses the application of mesenchymal stem cells and their secretory factors for skin and hair regeneration and reports no clinical results; the authors highlight the progress and call for practical applications.

This review highlights the importance of using 3D scaffolds in vitro to support hair follicle regeneration, emphasizing how these structures help maintain cell function and mimic the natural environment, which is crucial for developing hair follicle organoids for transplantation.

This review discusses the multiple layers of environmental controls on hair stem cell homeostasis and suggests that targeting these layers could offer safer regenerative medicine therapies without directly using stem cells.

This review article highlights recent progress and challenges in stem cell transplantation for regenerative medicine, emphasizing its potential in tissue repair for conditions like bone and cartilage injuries, neurological disorders, and blood diseases, while stressing the importance of overcoming current obstacles for future advancements.

This review discusses recent advances in scarless wound healing, focusing on strategies to create pro-regenerative scaffolds for repairing damaged skin, and reports no new clinical results.

This review synthesizes recent findings on the hair follicle stem cell niche and its complex interactions, exploring potential pathways for developing new hair growth therapies; it reports no new clinical results.

This review discusses hair follicle stem cells for wound healing and reports no new clinical results, noting their potential but emphasizing the need for further understanding and safety in clinical applications.

This study found that single high-dose irradiation in mice induced more severe acute skin injury and hair depigmentation, while fractional doses led to longer-term damage in the dermis and subcutis.

This study found that using cultured mesenchymal stem cells from mouse whisker hair follicle outer root sheath in wound healing reduced inflammation, accelerated closure, and resulted in less hypertrophic scarring in mice.

This review explores the molecular processes behind hair follicle stem cell activation and suggests new potential targets for designing therapies for various types of alopecia, but it reports no clinical results.

This study found that exosomes from human umbilical cord mesenchymal stem cells significantly promoted hair follicle growth and enhanced the transition to the growth phase in a model of androgenetic alopecia, by enriching specific microRNAs that activate key pathways involved in hair regeneration.

This review discusses the potential of adipose-derived stem cells for treating vitiligo, hair loss, and chronic wound healing, but reports no new clinical results and suggests the need for further investigation.

This review discusses the potential of stem cell-derived extracellular vesicles for improving diabetic wound healing and highlights their mechanisms, limitations, and challenges, but provides no new clinical findings.

This review summarizes the potential therapeutic applications of stem cells in dermatology, emphasizing their role in restorative and regenerative treatments through injections, topical applications, and scaffolds, supported by advancements in laboratory processes and quality control.

This review discusses the current challenges and strategies in hair follicle bioengineering for treating hair loss and reports no new clinical results; it highlights ongoing hurdles and future directions for developing functional hair regeneration therapies.

In this study on male androgenetic alopecia, the researchers reported significant increases in hair count, density, and thickness with minimal side effects over 6 weeks using adipose-derived stem cell conditioned media and minoxidil, but found no significant differences between concentrated and non-concentrated treatments.

This study discusses the potential of exosomes from human adipose-derived mesenchymal stem cells in enhancing dermal papilla cell proliferation via the Wnt/β-catenin pathway, suggesting a novel treatment approach for androgenetic alopecia by counteracting excessive dihydrotestosterone effects.

This study found that human adipose-derived MSC exosomes (hADSC-Exos) may enhance dermal papillary cell proliferation and migration by activating the Wnt/β-catenin signaling pathway, potentially reversing the effects of dihydrotestosterone in androgenetic alopecia.

This study identified TGF-β2 as a crucial signal in hair follicle stem cell regeneration, highlighting its role in counteracting BMP signaling to promote tissue regeneration.

In this study, human bone marrow mesenchymal stem cell-derived exosomes significantly accelerated cutaneous wound healing in rats by modulating the TGF-β/Smad signaling pathway.

This study identified highly variable genes in mesenchymal stem/stromal cells that are linked to classic functions like development and inflammation response, suggesting their potential as markers for further potency studies.

This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.

This article describes protocols for isolating and expanding human epidermal neural crest stem cells and discusses their potential for cell-based therapies in regenerative medicine, but reports no new clinical results.

This study found that activation of Wnt/β-catenin signaling in mouse testes promotes spermatogonial differentiation and reduces the stem cell pool, with SHISA6 inhibiting this process and maintaining stem cell characteristics.

This review discusses the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles and modern technologies like 3D bioprinting but reports no new clinical results.

This study found that incorporating adipose-derived stem cell conditioned medium into a polysaccharide hydrogel effectively reduced scar hyperplasia, with the combination offering better outcomes in preventing hypertrophic scarring compared to the medium alone in a rabbit ear model.

In this study, the researchers reported that activin B combined with bone marrow-derived mesenchymal stem cells enhanced wound healing and hair follicle regeneration in rats by promoting cell migration through the ERK and JNK pathways.

Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.

This study found that canine bulge-derived keratinocytes are highly proliferative and can reconstitute pilosebaceous structures, indicating their potential utility in studying human stem cell biology and hair disorders.