426 citations,
August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
245 citations,
January 2018 in “Bone Research” TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.
242 citations,
February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
83 citations,
May 2013 in “International Journal of Molecular Sciences” Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.
50 citations,
February 2007 in “Expert Opinion on Biological Therapy” Hair follicle stem cells could help repair nerves and avoid ethical issues linked to embryonic stem cells.
44 citations,
January 2015 in “Development” Human Schwann cells can be quickly made from hair follicle stem cells for nerve repair.
11 citations,
May 2022 in “Chinese medicine” Alpinetin helps grow hair by turning on hair stem cells and is safe for use.
11 citations,
August 2018 in “Facial Plastic Surgery Clinics of North America” Adipose-derived stem cells show potential for skin rejuvenation and wound healing but require more research to overcome challenges and ensure safety.
9 citations,
November 2018 in “Drug Discovery Today” Using skin stem cells and certain molecules might lead to scar-free skin healing.
6 citations,
November 2020 in “Molecular and Cellular Endocrinology” Androgens reduce BMP2, which weakens the ability of certain cells to help hair stem cells become different types of cells.
3 citations,
January 2023 in “Physiological Research” Conditioned media from mesenchymal stem cells show promise for tissue repair and disease treatment, but more research is needed on their safety and effectiveness.
3 citations,
November 2020 in “Planta medica international open” Plant-made bFGF helps cells grow and boosts collagen.
2 citations,
November 2022 in “Animal Bioscience” A specific RNA modification in cashmere goats helps activate hair growth-related stem cells.
January 2024 in “PloS one” Rat hair-follicle stem cells can become heart cells with specific supplements.
Valproic acid and rapamycin protect hair follicle stem cells from damage by activating a protective pathway.
October 2023 in “IBRO neuroscience reports” Rat hair follicle stem cells have functional oxytocin receptors, useful for studying neuropsychiatric disorders.
August 2022 in “Research Square (Research Square)” Implanted special stem cells from hair follicles helped heal wounds faster and with less scarring in mice.
May 2022 in “Research Square (Research Square)” Nestin marks cells that can become a specific type of skin cell in hair follicles of both developing and adult mice.
February 2020 in “Journal of chemical neuroanatomy” Researchers found a way to make rat hair follicle cells start turning into motor neuron-like cells, but couldn't fully turn them into working motor neurons.
August 2019 in “International journal of dermatology and venereology” The calcineurin/NFAT pathway plays a significant role in the development and growth of a type of skin cancer called cutaneous squamous cell carcinoma.
April 2019 in “Journal of Investigative Dermatology” Y27632 increases cell growth through EGFR signaling, not ROCK1/2.
Skin stem cells in hair follicles are important for touch sensation.
Wound healing involves three phases and various cells and factors, with scars typically forming in adults. Chronic wounds can occur due to various issues, and abnormal scarring can lead to hypertrophic or keloid scars. Emerging research areas include the role of proteins, microRNAs, macrophage manipulation, and stem cell treatment.
January 2015 in “Journal of Cytology and Histology” Hair loss in Androgenetic Alopecia is not caused by damage to follicular stem cells.
411 citations,
April 2010 in “Gastroenterology” Targeting colon cancer stem cells might lead to better treatment results.
291 citations,
April 2010 in “Gastroenterology” Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.
106 citations,
March 2014 in “BioEssays” We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.
98 citations,
December 2003 in “The FASEB Journal” Thymosin β4 promotes hair growth by activating stem cells in hair follicles.
43 citations,
June 2016 in “Clinics in Plastic Surgery” The conclusion is that fat grafting is safe and effective but carries risks that need careful management.
29 citations,
January 2017 in “Journal of Investigative Dermatology” The Msi2 protein helps keep hair follicle stem cells inactive, controlling hair growth and regeneration.