31 citations
,
January 2021 in “Experimental Dermatology” This review discusses recent advancements in generating appendage-bearing skin organoids from pluripotent stem cells and their potential applications in dermatological research, but reports no new clinical results.
21 citations
,
June 2018 in “Current Opinion in Genetics & Development” This review discusses recent advancements in regenerative medicine, including functional organ regeneration and the creation of mini-organs, and reports no new clinical results.
16 citations
,
April 2021 in “Frontiers in Cell and Developmental Biology” This review discusses human hair follicle development and highlights the potential of creating human in vitro models and skin substitutes with hair follicles, reporting no new clinical results.
April 2025 in “International Journal of Molecular Sciences” This review highlights the limitations of existing hair loss treatments like minoxidil and finasteride and suggests that future therapies may benefit from focusing on antibody and cell-based treatments, which offer targeted and potentially transformative options for managing hair loss disorders.
December 2025 in “Italian Journal of Anatomy and Embryology” This narrative literature review examined how linking embryonic development with non-genetic skin anomalies can improve diagnostic accuracy, guide prenatal counseling, and enrich dermatology education by revealing specific vulnerabilities in skin morphogenesis and supporting advances in regenerative medicine.
11 citations
,
May 2018 in “Philosophical Transactions of the Royal Society B” This review covers recent developments in materials for in vitro and in vivo stem cell manipulation, highlighting innovative substrate properties but does not report new experimental results.
4 citations
,
January 2024 in “The Scientific World JOURNAL” This paper reviews the molecular mechanisms involved in hair follicle development, highlighting their potential impact on human health and well-being, and discusses advancements in treating hair loss, enhancing wound healing, and developing cosmetic treatments.
3 citations
,
July 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study used scRNA-Seq to map the transcriptional changes during zebrafish hair cell regeneration, revealing distinct phases including injury response, transient regeneration gene activation, and reactivation of developmental programs.
2 citations
,
February 2024 in “Toxins” This study found that bee venom accelerated the transition from the telogen to anagen phase in mice, increasing hair growth by day 14, and suggested that bee venom may enhance adipose-derived stem cell activity by upregulating growth factor secretion.
November 2023 in “International Journal of Medical Sciences” This review examines the mechanisms of hair follicle development and regeneration, discussing current hair loss treatments and emerging therapies like low-level laser therapy and stem cell therapy, which the authors suggest show promise in managing hair loss.
April 2012 in “Annals of Neurosciences” This article discusses the development of the regenerative medicine field based on stem cells' capacity for in vitro differentiation, rather than actual organ or tissue regeneration.
January 2006 in “Durham e-Theses (Durham University)” This study reports for the first time on the expression patterns of Id2 and Id3 proteins in developing hair follicles, suggesting a significant role for these proteins in hair follicle development and epithelial-mesenchymal interactions.
This study found that finasteride could enhance the stemness of dermal papilla cells, suggesting potential benefits for hair regeneration approaches.
66 citations
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March 2019 in “Cellular and Molecular Life Sciences” This review discusses melanocyte development, emphasizing the plasticity of melanoblasts and the role of both intrinsic and extracellular signals in their differentiation and migration, with no new clinical results reported.
April 2018 in “Journal of Investigative Dermatology” This study found that arrector pili muscles formed by Sonic Hedgehog signaling play a critical role in maintaining sympathetic nerve connections to hair follicle stem cells, influencing hair regeneration, with implications for hair loss treatments.
401 citations
,
January 2013 in “Postepy Dermatologii I Alergologii” This review discusses the biology and development of skin melanocytes, but reports no new clinical findings.
137 citations
,
April 2015 in “Nature Reviews Molecular Cell Biology” This review discusses the distinct roles and surprising developmental flexibility of multiple somatic stem cell types in tissue maintenance and repair, reporting no new results but highlighting emerging questions about their regulation and origins.
38 citations
,
February 2016 in “Surgery Journal” This article discusses a wide range of procedures in facial plastic surgery and highlights the recent advancements and trends without reporting new clinical findings.
31 citations
,
July 2017 in “Clinical Science” This review discusses the role of microRNAs in skin function and potential therapeutic applications, emphasizing their importance in wound healing and disease management, though it reports no new experimental findings.
3 citations
,
September 2022 in “Frontiers in veterinary science” This study identified key genes and signaling pathways involved in cashmere goat hair follicle growth cycles, influenced by melatonin implantation, suggesting a basis for further research on melatonin's regulatory mechanism.
July 2025 in “Microscopy and Microanalysis” In this research, scientists developed a compression therapy model using immobilized mice, successfully analyzing skin without causing injury, and observed increased epidermal thickness and changes in adipocyte volume, with no increase in DNA damage markers.
January 2014 in “Max Planck Digital Library” This research describes mouse models to explore Kindlin-1's role in skin disorders, including Kindler syndrome, revealing novel integrin-independent pathways potentially leading to skin tumors.
January 2026 in “British Journal of Dermatology” This study suggests that ELF5 plays a crucial role as a regulator and maintainer of stem/progenitor cell functions, impacting normal skin development and homeostasis.
161 citations
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August 2012 in “Seminars in cell & developmental biology” This review discusses the molecular mechanisms involved in hair follicle development and regeneration, highlighting findings from mouse genetic studies, and reports no new experimental results.
89 citations
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November 2017 in “Journal of Cellular Physiology” This review discusses the role of Wnt/β‐catenin signaling in stem and cancer stem cell maintenance and its involvement in the development and regeneration of various organs, but reports no new experimental results.
15 citations
,
January 2018 in “Biomedical Reports” This review discusses multiple pathways through which exosomes may regulate skin functions and diseases like melanoma, scleroderma, and pigmentation disorders, without providing new clinical results; future therapeutic strategies are suggested.
13 citations
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January 2021 in “Journal of Cellular and Molecular Medicine” This review discusses the roles and mechanisms of thymosin β4 in hair follicle growth and development but reports no new experimental findings; the authors emphasize the need for further research on its molecular pathways.
January 2018 in “Contributions to management science” This review discusses the role of microRNA in skin development and disease, highlighting its potential for novel therapies, and reports no clinical results.
4 citations
,
April 2002 in “Medical Hypotheses” Hormones cause hair loss by affecting cell growth and weakening cell attraction.
43 citations
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January 2012 in “Biological Research” This review discusses the embryonic origins and characteristics of various stem cell populations in the skin, but it provides no new experimental results.