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In this study, researchers found that selectively disabling ribonucleotide excision repair in mouse epidermis caused DNA damage, skin inflammation, and led to skin cancer, suggesting a potential role for this repair mechanism in tumorigenesis.

This study found that selectively inactivating ribonucleotide excision repair in mouse epidermis leads to DNA damage, keratinocyte intraepithelial neoplasia, and squamous cell carcinoma, indicating a potential tumor-promoting mechanism related to compromised genome maintenance.

This study found that selective inactivation of ribonucleotide excision repair in mouse epidermis led to spontaneous DNA damage, skin inflammation, and the development of squamous cell carcinoma, suggesting potential implications for cancer development in humans.

This study found that the transcription factor Gata6 plays a crucial role in adult mouse hair follicle regeneration by promoting the renewal and preventing DNA damage of rapidly proliferating progenitor cells.

The researchers reported that dsRNA from damaged skin activates TLR3, promoting hair follicle regeneration, while TLR3-deficient animals fail to initiate this process, suggesting potential therapeutic approaches for hair neogenesis.

In this study, the deletion of NIPP1 in keratinocytes led to chronic skin inflammation and epidermal changes in mice, with early cell-cycle arrest and premature senescence observed, potentially contributing to reduced mutagen sensitivity.

This study found that topically applied nano-Zinc oxide accumulated in hair follicles and induced apoptosis in hair follicle stem cells, indicating a potential risk to skin homeostasis.

The study found that aging in hair follicle stem cells leads to hair follicle miniaturization and eventual hair loss in both wild-type mice and humans by proteolyzing type XVII collagen.

This study found that disrupted cholesterol homeostasis impairs hair regrowth in individuals with primary cicatricial alopecia by damaging hair follicle stem cells, highlighting the importance of cholesterol in maintaining stem cell function and hair follicle integrity.

This review discusses manipulating the stem cell niche as a strategy in regenerative medicine to repair damaged tissues, highlighting the potential benefits and challenges but reporting no new results.

This study found that the Stem Cell Educator therapy improved hair regrowth and quality of life in patients with severe alopecia areata by restoring immune balance and protecting hair follicles from autoimmune damage.

This study reported that molecules from Zebrafish embryo cell differentiation can counteract neurodegeneration, regenerate tissues, and potentially reverse hair follicle damage in androgenetic alopecia.

In this study, researchers found that deleting the Bmi1 gene in murine melanocytes caused premature hair greying and loss of melanocyte lineage cells, highlighting BMI1's role in protecting melanocyte stem cells from stress and oxidative damage.

This study reported that exosomes derived from human amniotic mesenchymal stem cells (hAMSC-exo) accelerated hair growth in androgenetic alopecia mice by enhancing signals between hair follicle cells and improving cellular environments, particularly protecting against dihydrotestosterone-induced damage via Wnt/β-catenin signaling.

This review discusses how chronic inflammation can lead to persistent stem cell activation and DNA damage, ultimately promoting cancer development and metastasis, but reports no new results.

This study discovered that exosomes from adipose-derived mesenchymal stem cells can mitigate damage in dermal papilla cells by modulating the TGF-β1/SMAD2 signaling pathway through miRNAs miR-574-3p and miR-125a-5p, revealing potential therapeutic targets for androgenetic alopecia.

This study observed that while X-ray radiation did not alter major hair keratin composition in mice, it decreased hair follicle stem cell markers and increased Krt5, suggesting potential as a radiation biomarker.

Tanshinone IIA helps protect skin tissue from low oxygen damage by boosting certain cell markers.

This study found that mouse astrocytes formed cell spheres on agarose surfaces, acquired stem cell-like features, and their derived stem cells effectively differentiated into neurons that helped regenerate damaged nerves.

This review highlights pigment epithelium-derived factor's roles in ageing and development, focusing on its antioxidant functions and support of stem cell survival, but reports no new experimental results.

In this study, intranasal delivery of hair follicle-derived stem cells improved neurological function and reduced brain damage in a rat model of ischemic stroke.

This study found that anagen hair follicles can quickly regenerate after radiation damage by forming new progenitor cells outside the bulge, bypassing the need for telogen entry.

This review concluded that chronic inflammation can lead to persistent activation of stem cells, accumulating DNA damage and promoting cancer development and metastasis from stem cell origins.

This review concludes that chronic inflammation can lead to persistent activation of stem cells, accumulating DNA damage that promotes cancer development and metastasis, by affecting normal stem cells, cancer stem cells, and cancer cells.

This review highlights that chronic inflammation leads to ongoing activation of stem cells, causing DNA damage accumulation, which can promote cancer development and metastasis.

This review concludes that chronic inflammation persistently activates stem cells, leading to DNA damage accumulation that can promote cancer development and metastasis, affecting both stem and cancer cells.

In this review, researchers concluded that chronic inflammation perpetually activates stem cells, allowing DNA damage accumulation and potentially promoting cancer development and metastasis by converting stem cells into cancer cells.

This literature review reports that chronic inflammation can lead to persistent activation of stem cells, accumulating DNA damage, and eventually promoting cancer development and metastasis even before stem cells become cancerous.

This review concludes that chronic inflammation can lead to persistent activation of stem cells, which may accumulate DNA damage and ultimately promote cancer, while also facilitating cancer metastasis.

This review outlines the classification, histopathologic presentation, and pathogenetic concepts of scarring and nonscarring alopecias, reporting no new clinical results and emphasizing the need for clinicopathologic correlation.