Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that VR1 activation in human hair follicles inhibited hair growth by suppressing proliferation and promoting apoptosis, suggesting VR1 plays an important role in hair growth regulation.

This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.

The study found that over-expressing ornithine decarboxylase in the outer root sheath of the hair follicle in mice increases UVB-induced tumor growth and invasive squamous cell carcinoma compared to inter-follicular epidermal keratinocytes.

This study explored the complex developmental processes of human hair, emphasizing the intricate interactions required for hair follicle morphogenesis and its implications for drug incorporation and concentration interpretation, particularly in early childhood.

This study found that in Pomeranians with Alopecia X, key genes in the Wnt and Shh signaling pathways and stem cell markers are downregulated, which may explain the absence of anagen hair follicles.

This review summarizes the roles of matricellular proteins in skin stem cell niches, highlighting their contribution to stem cell fate, self-renewal, and potential implications for wound healing and aging.

This study suggests that cultured human hair follicle cells can potentially recreate epidermis and produce bioengineered hair follicles in a GMP cell factory for regenerative therapy in alopecia.

MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.

This study found that targeting IL-17 signaling in aged skin reduces inflammation and delays age-related traits, suggesting a potential strategy to prevent age-associated skin ailments.

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

Stem cells are in deep skin layers, while differentiating cells are in shallow layers.

This study found that upper-bulge epidermal stem cells in mouse hair follicles are specialized for nerve interactions, crucial for forming tactile sensory units, and influence touch responses via EGFL6 and αv integrin pathways.

This review examines recent developments in tooth regeneration therapies using mesenchymal stem cells, but it reports no new clinical findings.

This review discusses the role and plasticity of epidermal stem cells in skin maintenance, wound repair, and cancer, noting recent insights from advanced technologies but providing no new clinical results.

This study revealed that telocytes are crucial Wnt-producing niche cells necessary for hair follicle regeneration in mice, with their removal or the absence of their Wnt signals halting the regenerative process.

This study found that prostaglandin D2 reduced proliferation in bulge resident K15+ stem cells but not in other K15+ progenitor cells, suggesting differential impacts on hair follicle stem cell niches.

This study suggests that interfollicular epidermal keratinocytes with stem-like features may serve as an alternative to follicular keratinocytes for hair regeneration by supporting hair follicle morphogenesis in vivo.

This study found that Rac1 activity in specific skin compartments is sufficient for hair formation, but results in hair with altered structure and pigmentation compared to normal.

The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.

This study found that Wnt/β‐catenin signaling influences the hair follicle regeneration process by prompting quiescent stem cells to enter the cell cycle and is necessary for maintaining the stem cell pool.

This study suggests that human embryonic stem cells may improve skin graft quality and functionality by enabling the identification and amplification of early ectodermal progenitors, pending confirmation from preclinical studies.

In this study, transgenic male mice over-expressing the androgen receptor in mesenchymal stem cells showed reduced fat mass and improved glucose clearance, suggesting enhanced androgen sensitivity may alter body composition.

This review highlights recent advances in understanding how the extracellular matrix regulates epidermal stem cell fate, emphasizing the importance of the hair follicle stem cell niche, but reports no new empirical findings.

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

This research discusses a novel imaging approach in live mice to study stem cell and niche interactions in tissue homeostasis and reports no new results.

This review discusses the latest understanding of androgenetic alopecia, including stem cell niches in hair follicles, and highlights emerging treatments like growth factors and platelet-rich plasma without new clinical findings.

This review discusses the complex role of Runx family genes in regulating stem cells in blood and skin tissues and reports no new experimental results.

In this research, the authors identify coordinated mechanical forces as crucial for hair follicle development in mammals, with contractile, proliferative, and proteolytic activities facilitating the formation and sectioning of epithelial structures crucial for forming a functional tissue.

This study found that Polycomb repressive complex 1 is crucial for skin development and stem cell specification, influencing gene activity beyond its known repressor functions.

In this study, the researchers found that deleting ceramide synthase 4 in the skin's epidermis alters stem cell differentiation, disrupting hair follicle structure and barrier function, potentially leading to immune responses similar to atopic dermatitis.