Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that the anti-apoptotic Bcl-2 protein plays a crucial role in maintaining hair follicle stem cell function and influences tissue regeneration and tumor formation in mice.

This study found that the repressive histone mark H2AK119ub links inhibitory FGF signals with the quiescent state in hair follicle stem cells, revealing a signaling-epigenetic axis crucial for maintaining stem cell quiescence and tissue homeostasis.

In cashmere goats, this study found that reducing miR-361-5p levels activates secondary hair follicle stem cells by upregulating the FOXM1 gene, which in turn stimulates the Wnt/β-catenin pathway, crucial for cashmere fiber morphogenesis.

This study found that, in mouse tail epidermis, stem cells rapidly activate and regenerate new progenitors to repair wounds, with mechanisms affecting their proliferation, differentiation, and migration.

The study reports that Fgf18 and Tgf-β2 signaling pathways in hair follicle stem cells have opposing effects on the timing of hair cycle transitions, influencing the shift from telogen to anagen phases.

In this study using a mouse model of Pemphigus vulgaris, researchers found that loss of desmoglein 3 adhesion in hair follicle stem cells triggers a regenerative program restoring stem cell function, requiring Hedgehog pathway suppression.

This study found that transient non-lethal levels of endogenous ROS in cultured human hair follicles promoted entry into the growth phase by activating the hair follicle stem cell niche.

This study concluded that label-retaining cells in mouse epidermis differ in their sensitivity to proliferative stimuli, influencing their division and potential transdifferentiation without consistently depleting their population.

In this study using a transgenic mouse model, Id2 overexpression in hair follicle stem cells prolonged quiescence by affecting gene expression, partly independent from BMP signaling.

This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.

In this study, researchers differentiated induced pluripotent stem cells into cells with dermal papilla-like properties, demonstrating their potential role in hair follicle bioengineering and drug testing for hair growth.

This review discusses the regulation and dynamics of the Wnt/β-catenin signaling pathway in development, pluripotency, and cancer, highlighting potential mechanisms and future research directions, but reports no new results.

This review explores recent insights into how intrinsic gene oscillations and molecular interactions in hair follicle stem cells contribute to their regenerative potential, with potential implications for regenerative medicine, but reports no new clinical results.

This article reviews how stem cell exhaustion contributes to aging, emphasizing the balance between proliferation and quiescence as crucial for long-term stem cell maintenance, but it reports no new results.

This study found that canine hair follicle stem cells in vitro expressed markers associated with multipotency, suggesting their potential role in the hair cycle.

This study identifies unique gene expression patterns in specialized fibroblasts within adult hair follicles, which advances understanding of their role in tissue regeneration.

This review discusses the roles of interferon-γ and PPAR-γ-mediated signalling in scarring alopecia, suggesting these pathways as potential therapeutic targets, but it reports no new empirical results.

PPAR-γ agonists like pioglitazone may help manage lichen planopilaris but don't fully reverse scarring.

This study found that using three-dimensional cell culture with Matrigel enhances the biological function and stemness of stem cells, leading to improved soft tissue repair and healing by activating the host microenvironment and autologous stem cells.

This study found that PRC1 plays crucial roles in skin epithelial stem cell regulation, with catalytic and non-catalytic functions impacting epidermal integrity, hair development, and Merkel cell dynamics in murine models.

This study found that the combination of TTNPB and CHIR99021 enhanced the derivation of highly advanced neural stem cells from human pluripotent stem cells, with improved chromatin accessibility and neuroectodermal gene expression, and these cells successfully engrafted in rat hippocampi to ameliorate depression-like symptoms.

This review examines a study showing that the balding scalp in men with androgenetic alopecia retains stem cells but lacks certain progenitor cells, suggesting new targets for future therapies; it reports no clinical results.

This study found that activating Toll-like receptor 3 in periodontal ligament stem cells enhanced their stem cell and immunosuppressive properties, potentially supporting effective periodontal tissue regeneration.

This study found that neural stem cell extract enhanced hair growth in mice and cells by stimulating hair follicle niches and activating signaling pathways like TGF-β and BMP.

In this study, researchers found that disrupting desmoglein 3 signaling in a mouse model of pemphigus vulgaris activates normally quiescent hair follicle stem cells, compromising their multipotency but prompting a regenerative response that restores stem cell function and structures.

This study found that ectodermal precursor cells derived from human induced pluripotent stem cells may enhance hair follicle morphogenesis through improved epithelial-mesenchymal interactions when cocultured with dermal cells.

This study found that Caspase-1, traditionally viewed as an inflammasome component, is secreted upon wounding and plays a novel role by triggering hair follicle stem cell migration into the epidermis, offering insights into epithelial hyperplasia mechanisms in inflammatory skin conditions.

This study suggests that decreased PPARgamma function may trigger the pathogenesis of lichen planopilaris, and PPARgamma-targeted therapy could be a potential treatment method.

This study found that in mice, hyper-activated JAK-STAT1 signaling due to EGFR inhibitor treatment leads to scarring alopecia, but JAK1/2 inhibition can restore hair follicle immune privilege and promote new hair growth.

Laser treatment boosts hair growth by activating a key growth factor.