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    Glossary Stem Cell Activation

    process stimulating dormant cells to divide and specialize

    Stem cell activation refers to the process by which dormant stem cells are stimulated to begin dividing and differentiating into specialized cell types. This is crucial for tissue repair and regeneration, as well as for maintaining healthy hair growth. In the context of hair, activating stem cells in hair follicles can potentially reverse conditions like alopecia by promoting the growth of new hair.

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    1. Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering Expert Opinion on Biological Therapy · 2013 · 74 citations
    2. The incidental pore: Ca<sub>V</sub>1.2 and stem cell activation in quiescent hair follicles Genes & development · 2013 · 3 citations
    3. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 1 citations
    4. Faculty Opinions recommendation of Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
    5. Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation Cells · 2022 · 12 citations
    6. 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification Journal of Investigative Dermatology · 2018 · 1 citations
    7. 572 Olfactory Receptor 2A4/7 Activation by the Fragrance, Cyclohexyl Salicylate, Promotes Human Hair Follicle Growth and Stem Cell Progeny Expansion Journal of Investigative Dermatology · 2022
    8. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 72 citations
    9. LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis Journal of Investigative Dermatology · 2024 · 1 citations
    10. Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development · 2003 · 182 citations
    11. Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration Histochemistry and Cell Biology · 2017 · 30 citations
    12. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis Stem Cell Research & Therapy · 2019 · 26 citations
    13. RETRACTED: Tanshinone IIA Pretreatment Renders Free Flaps against Hypoxic Injury through Activating Wnt Signaling and Upregulating Stem Cell-Related Biomarkers International Journal of Molecular Sciences · 2014 · 6 citations
    14. Lactate dehydrogenase activity drives hair follicle stem cell activation Nature cell biology · 2017 · 202 citations
    15. mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration 2015 · 71 citations
    16. Glutamate transporter Slc1a3 mediates inter‐niche stem cell activation during skin growth EMBO journal · 2018 · 34 citations
    17. TCDD-induced activation of aryl hydrocarbon receptor regulates the skin stem cell population Medical hypotheses · 2015 · 9 citations
    18. Decision letter: Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells 2017
    19. 277 HPV8 E6 induced STAT3 activation leads to hair follicle junctional zone keratinocyte stem cell proliferation and expansion in actinic keratoses 2023
    20. Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway Stem Cell Research & Therapy · 2025
    21. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012 · 321 citations
    22. Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice Journal of diabetes research · 2022 · 6 citations
    23. Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis 2024
    24. Additional file 1 of Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis Figshare · 2024
    25. Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis Research Square (Research Square) · 2023
    26. 568 Autophagy Controls Epidermal Tumour Formation and Hair Follicle Stem Cell Activation Journal of Investigative Dermatology · 2022
    27. Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation Proceedings of the National Academy of Sciences · 2013 · 176 citations
    28. Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations Molecular Carcinogenesis · 2013 · 23 citations
    29. Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Preserve Melanocyte Stem Cell Integrity Under Acute Neurogenic Oxidative Stress via Activation of the Nrf2– ARE Pathway in C57BL / 6J Mice Journal of Cosmetic Dermatology · 2026
    30. Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/β-Catenin Pathway Stem Cells International · 2023