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Glossary Stearoyl-CoA Desaturase 1

enzyme converting saturated fatty acids to monounsaturated fatty acids

Stearoyl-CoA Desaturase 1 (SCD1) is an enzyme that plays a crucial role in the metabolism of fatty acids. It converts saturated fatty acids into monounsaturated fatty acids, which are important for maintaining cell membrane fluidity and producing signaling molecules. This enzyme is significant in various biological processes, including lipid metabolism and energy homeostasis, and has been linked to conditions like obesity, diabetes, and certain skin disorders.

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research Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

67 citations , December 2013 in “Journal of Biological Chemistry”

This review discusses the role of the enzyme Δ9-desaturase-1 in skin lipid regulation and whole-body energy balance in mice and reports no new experimental results.

research Scd1 ab-Xyk : a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse

12 citations , July 2004 in “Molecular genetics and genomics”

This study identifies a new mutation in the Scd1 gene in a strain of Kunming mice, causing skin and hair defects with the mildest impact among similar mutations.

research Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1 ^-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation

87 citations , March 2007 in “Biological Chemistry”

In this study, targeted deletion of the stearoyl-CoA desaturase 1 gene in mice disrupted the epidermal lipid barrier, leading to increased water loss, impaired thermoregulation, and metabolic issues.

research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

25 citations , February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, topical application of the SCD1 inhibitor XEN103 significantly reduced sebaceous gland size and number in mouse skin, suggesting potential local therapeutic effects for acne treatment without systemic side effects.

research Differentiation of the sebaceous gland

60 citations , March 2009 in “Dermato-Endocrinology”

This review highlights recent findings on the importance of signalling pathways in sebaceous gland morphogenesis and differentiation, but reports no new clinical results.

research SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

4 citations , December 2022 in “Advanced science”

This study found that fatty acid desaturation regulated by SCD1 is crucial for hair growth by maintaining hair follicle stem cell niches, with its absence causing abnormal hair growth in mice.

research Hot Stuff: Thermal Imaging Aids in Cellulitis Diagnosis

4 citations , February 2018 in “Journal of Investigative Dermatology”

This study suggests that thermal imaging may aid in diagnosing cellulitis, potentially improving patient care, although its applicability to certain cases requires further investigation.

research Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche

March 2023 in “Scientific reports”

This study presents evidence that hair matrix progenitors and the enzyme Stearoyl CoA Desaturase 1 may play a role in maintaining the dermal papilla niche via autocrine Wnt and paracrine Hedgehog signaling in mice.

research Skin Stearoyl-CoA Desaturase Genes

1 citations , January 2013

research Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry

71 citations , January 2014 in “Journal of Proteome Research”

In this study, distinct metabolic profiles were identified in women with PCOS, suggesting potential biomarkers for diagnosis based on changes in lipid and androgen metabolism.

research 1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity

5 citations , April 2014 in “Journal of Lipid Research”

This study demonstrates a method to noninvasively assess lipid classes in rodent sebum via high-field proton NMR, observing significant lipid reductions in rats treated with an SCD1 inhibitor.

research Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice

22 citations , August 2013 in “Experimental Dermatology”

In this study, the researchers found that constitutive activation of the EGFR in mice led to increased sebum production, enlarged sebaceous glands, and altered gene expression related to sebocyte proliferation and lipogenesis.

research Acyl-CoA binding protein and epidermal barrier function

15 citations , March 2014 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

This review discusses the role of acyl-CoA binding protein (ACBP) in the epidermal barrier, noting that its disruption in mice is linked to skin and fur abnormalities; it reports no new clinical results.

research Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia

14 citations , October 2018 in “PloS one”

In this study, Far2-/- mice were observed to develop focal alopecia with altered sebaceous gland morphology and lower skin lipid levels compared to wildtype mice.

research The acyl-CoA binding protein is required for normal epidermal barrier function in mice

31 citations , July 2012 in “Journal of Lipid Research”

This study found that the acyl-CoA binding protein is essential for the production of very long chain free fatty acids in the stratum corneum and maintaining normal epidermal barrier function in mice.

research Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis

5 citations , February 2025 in “Cell Reports”

In this study, inducible whole-body Acly-knockout mice revealed that ACLY is essential for skin homeostasis, as its deficiency led to increased sebum production and skin abnormalities, indicating a vital role for cytosolic acetyl-CoA synthesis in preserving skin barrier integrity and systemic lipid regulation.

research Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5

18 citations , June 2017 in “Proceedings of the National Academy of Sciences of the United States of America”

In this mouse study, hair growth defects associated with the Gk5 null allele were partially alleviated by simvastatin treatment, suggesting GK5 plays a key role in skin-specific cholesterol regulation.

research 666 Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in follicular dystrophy and primary cicatricial alopecia

April 2018 in “Journal of Investigative Dermatology”

Mutations in Far2 mice cause hair loss due to sebaceous gland issues.

research Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes

8 citations , January 2019 in “Annals of Dermatology”

Among cultured sebocytes, this study found that bilobetin significantly inhibited lipid production induced by IGF-1, suggesting potential for use in acne treatment.

research Mutations in Sterol O-Acyltransferase 1 (Soat1) Result in Hair Interior Defects in AKR/J Mice

23 citations , June 2010 in “Journal of Investigative Dermatology”

This study found that the hair interior defect in AKR/J mice is linked to a mutation in the Soat1 gene, which disrupts SOAT1 protein expression and affects lipid metabolism critical for normal hair formation.

research Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers

33 citations , March 2013 in “Journal of Investigative Dermatology”

Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.

research Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

138 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

This review discusses how Western diet may contribute to acne vulgaris through insulin signaling and metabolomic changes, promoting a dietary approach for management, but reports no new experimental results.

research The Browning of White Adipose Tissue: Some Burning Issues

437 citations , August 2014 in “Cell metabolism”

This perspective suggests that browning agents may not directly enhance UCP1 expression in white adipose tissue but instead induce browning through increased heat loss, prompting thermogenesis to compensate.

research Expression of steroidogenic enzymes in human sebaceous glands

25 citations , June 2014 in “Journal of Endocrinology/Journal of endocrinology”

This study found that local androgen biosynthesis and metabolism in human sebaceous glands play a crucial role in sebum synthesis and secretion.

research Emerging Therapies for Acne Vulgaris

22 citations , March 2018 in “American Journal of Clinical Dermatology”

New acne treatments show promise as alternatives to traditional therapies.

research Anti-acne drugs in phase 1 and 2 clinical trials

27 citations , June 2017 in “Expert opinion on investigational drugs”

This review discusses ongoing and past trials for novel acne treatments, focusing on topical agents with potential sebosuppressive, antimicrobial, or anti-inflammatory effects, without reporting new clinical results.

research Lichen Planopilaris

July 2018 in “Elsevier eBooks”

This study highlights lichen planopilaris as a form of scarring hair loss with symptoms like shedding and itching, and notes successful treatment options such as topical and oral antiinflammatory medications to preserve hair follicles by early intervention.

research Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress

88 citations , August 2014 in “PLOS genetics”

This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.

research Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria

29 citations , December 2017 in “Molecular therapy”

This study found that enzyme replacement therapy in mice with a severe form of classical homocystinuria improved metabolic patterns and alleviated many clinical symptoms.

research Cicatricial Alopecia Research Foundation meeting, May 2016: Progress towards the diagnosis, treatment and cure of primary cicatricial alopecias

22 citations , January 2018 in “Experimental Dermatology”

This article reviews insights into the pathogenesis of primary cicatricial alopecias, such as lichen planopilaris, provided by emerging technologies, but it does not report new clinical results.