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    Did you mean Stearoyl-CoA Desaturase 1?
    Glossary Stearoyl-CoA Desaturase 1

    enzyme converting saturated fatty acids to monounsaturated fatty acids

    Stearoyl-CoA Desaturase 1 (SCD1) is an enzyme that plays a crucial role in the metabolism of fatty acids. It converts saturated fatty acids into monounsaturated fatty acids, which are important for maintaining cell membrane fluidity and producing signaling molecules. This enzyme is significant in various biological processes, including lipid metabolism and energy homeostasis, and has been linked to conditions like obesity, diabetes, and certain skin disorders.

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    Research 30 of 204

    1. Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance Journal of Biological Chemistry · 2013 · 67 citations
    2. Scd1 ab-Xyk : a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse Molecular genetics and genomics · 2004 · 12 citations
    3. Obesity resistance of the stearoyl-CoA desaturase-deficient (<i>scd1</i> <sup>-/-</sup>) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation Biological Chemistry · 2007 · 87 citations
    4. Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands 2013 · 25 citations
    5. Differentiation of the sebaceous gland Dermato-Endocrinology · 2009 · 60 citations
    6. SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes Advanced science · 2022 · 4 citations
    7. Hot Stuff: Thermal Imaging Aids in Cellulitis Diagnosis Journal of Investigative Dermatology · 2018 · 4 citations
    8. Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche Scientific reports · 2023
    9. Skin Stearoyl-CoA Desaturase Genes 2013 · 1 citations
    10. Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry Journal of Proteome Research · 2014 · 71 citations
    11. 1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity Journal of Lipid Research · 2014 · 5 citations
    12. Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice Experimental Dermatology · 2013 · 22 citations
    13. The acyl-CoA binding protein is required for normal epidermal barrier function in mice Journal of Lipid Research · 2012 · 31 citations
    14. Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis Cell Reports · 2025 · 5 citations
    15. Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia PloS one · 2018 · 14 citations
    16. Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5 Proceedings of the National Academy of Sciences of the United States of America · 2017 · 18 citations
    17. 666 Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in follicular dystrophy and primary cicatricial alopecia Journal of Investigative Dermatology · 2018
    18. Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes Annals of Dermatology · 2019 · 8 citations
    19. Mutations in Sterol O-Acyltransferase 1 (Soat1) Result in Hair Interior Defects in AKR/J Mice Journal of Investigative Dermatology · 2010 · 23 citations
    20. Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers Journal of Investigative Dermatology · 2013 · 33 citations
    21. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update Clinical, Cosmetic and Investigational Dermatology · 2015 · 138 citations
    22. Emerging Therapies for Acne Vulgaris American Journal of Clinical Dermatology · 2018 · 22 citations
    23. Anti-acne drugs in phase 1 and 2 clinical trials Expert opinion on investigational drugs · 2017 · 27 citations
    24. Lichen Planopilaris Elsevier eBooks · 2018
    25. Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress PLOS genetics · 2014 · 88 citations
    26. Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria Molecular therapy · 2017 · 29 citations
    27. Cicatricial Alopecia Research Foundation meeting, May 2016: Progress towards the diagnosis, treatment and cure of primary cicatricial alopecias Experimental Dermatology · 2018 · 22 citations
    28. Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis American Journal of Physiology-endocrinology and Metabolism · 2013 · 14 citations
    29. Decreased Serum Ferritin is Associated With Alopecia in Women Journal of Investigative Dermatology · 2003 · 163 citations
    30. Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome International Journal of Molecular Sciences · 2020 · 58 citations