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January 2018 in “Skin appendage disorders” This review discusses the role of the complement pathway in alopecia areata and reports no new clinical results; the authors suggest that targeting this pathway could offer treatment options.
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January 2018 in “Methods in molecular biology” This research describes methods to activate melanocyte stem cells during hair follicle regeneration and to isolate melanocytes from neonatal mouse skin, with the aim of studying melanogenesis for potential clinical applications.
March 2026 in “Dermatopathology” In this case report, a rare instance of a primary cutaneous granular cell tumor with prominent overlying terminal hair growth in an adult is described, highlighting the importance of recognizing atypical presentations to accurately diagnose similar uncommon neoplasms.
January 2026 in “Frontiers in biomedical technologies” In this study, high-resolution ultrasound imaging revealed that DHT administration in male C57BL/6 mice leads to increased epidermal and dermal thicknesses and decreased skin elasticity, simulating structural changes associated with Androgenetic Alopecia.
July 2025 in “Journal of Investigative Dermatology” Three molecular subtypes of advanced skin T-cell lymphoma were identified, with potential biomarkers for predicting treatment response and disease progression.
This study observed that TBX3 mRNA expression levels were region-specific and correlated with pigmentation patterns in dun Mongolian horses, providing insights into the genetic mechanisms behind their distinctive Bider markings.
October 2024 in “Dermatologica Sinica” This study highlights the distinct distribution patterns of extracellular matrix components in the scalp skin of male and female androgenetic alopecia patients, with increased elastin staining intensity observed in male cases.
May 2024 in “Scientific Reports” In this study, researchers examined androgen receptor activity in the adult mouse brain and found specific expression in key brain areas, which could inform understanding of cognitive side effects in humans undergoing androgen deprivation therapy for prostate cancer.
March 2024 in “Tissue engineering. Part A” In this study, researchers observed that applying negative pressure to nude mice led to a significant increase in hair follicle growth and angiogenesis, suggesting potential for hair regeneration through mechanisms involving SOX-9, LHX-2, and β-catenin mediation.
March 2024 in “Nihon Keshouhin Gijutsushakaishi/Journal of S C C./Nihon Keshouhin Gijutsushakai kaishi” This study found that decreased expression of the protein transglutaminase 3 with age may lead to reduced zinc levels in hair cuticles, contributing to hair thinning.
February 2024 in “Advanced Science” This study highlights that a novel radially aligned nanofiber scaffold with dual growth factor gradients significantly enhances wound healing, promoting cell migration, epidermal regeneration, and angiogenesis, ultimately leading to improved wound closure, immune regulation, and tissue remodeling compared to other groups.
December 2023 in “Chiwi'saeng'gwa haghoeji” Hair keratin protein might help heal mouth wounds faster.
December 2023 in “Scientific reports” This study assessed three lactic acid bacteria-fermented proteins and found that F-WPI and F-SPI could normalize osteoclastogenesis markers in vitro, while F-SPI enhanced osteoblastogenesis markers, suggesting potential as dietary supplements for osteoporosis prevention, though further research into mechanisms is needed.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that hemoglobin α expression in the epidermis is induced by oxidative stress and may function as an antioxidant, contributing to skin barrier function.
September 2023 in “Çukurova medical journal (Online)/Çukurova medical journal” This study observed that EZH2 expression scores in the epidermis, dermis, and hair follicles decrease with gestational age in human fetuses, and these scores were significantly higher in adults, indicating that lower EZH2 levels may be required for full skin differentiation and maturation before birth.
In this study, researchers observed a high degree of plasticity in somatosensory axons innervating Merkel cells in adult mouse skin, with both epithelial and neural components exhibiting dynamic remodeling, highlighting intricate epithelial-neural interactions in maintaining homeostasis.
April 2023 in “Dermatology practical & conceptual” This study concluded that lenalidomide significantly induces the proliferation and migration of melanocyte stem cells, enhancing their differentiation into functional melanocytes in a mouse model.
April 2023 in “Authorea (Authorea)” This case report describes the presentation of a 32-year-old Iranian immunocompetent female diagnosed with Merkel Cell Carcinoma, highlighting the importance of early diagnosis and management to mitigate complications.
March 2023 in “Revista médica Clínica Las Condes” This study observed a tendency for patients with frontal fibrosing alopecia to have more androgen receptors in their scalp than healthy controls, though this difference was not statistically significant.
November 2022 in “Journal of Investigative Dermatology” This study found that the immunological characterization of ichthyoses as psoriasiform or atopic patterns could help improve treatment, highlighting the need for targeted therapies to address itch and skin inflammation.
March 2022 in “Indian Journal of Animal Research” In this study, canine hair follicle stem cells were shown to be multipotent, capable of differentiating into various cell types like adipocytes in vitro.
April 2020 in “International journal of clinical and diagnostic pathology” This study examined Bcl-2 and COX-2 expression in Lichen Planus cases, highlighting their roles in apoptosis protection and inflammation, with results analyzed statistically.
This study found that mutations in the PADI3 gene, which is important for hair shaft formation, may contribute to central centrifugal cicatricial alopecia among patients.
April 2018 in “Journal of Investigative Dermatology” This study found that claudins CLDN1 and CLDN3 are crucial for maintaining proper hair follicle structure in mice, and their dysregulation may lead to telogen hair loss.
September 2017 in “Journal of Investigative Dermatology” This study found that their novel 3D-imaging method, ASAXA-μCT, identified shrinkage of sweat glands as a key factor in skin aging, which leads to dermal defects, decreased elasticity, and increased wrinkling and sagging.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Quantitative Mass Spectrometry Imaging offers precise localization and quantification of active compounds in skin tissues, demonstrating benefits over traditional LC-MS in drug penetration studies.
January 2017 in “Postepy Dermatologii I Alergologii” This study investigates the potential role of the corticotropin-releasing hormone system in the pathogenesis of lichen planus but does not report new clinical results, emphasizing the need for further exploration.
January 2017 in “DR-NTU (Nanyang Technological University)” This study observed that keratin sponges showed comparable biocompatibility to a commercial positive control in mice, but keratin gels had slightly inferior biocompatibility.
December 2016 in “Chin J Anat Clin” This study successfully improved methods for isolating, culturing, and purifying rat hair follicle stem cells, demonstrating their high purity, strong proliferation, and potential for adipogenic and osteogenic differentiation in vitro, which could support advancements in tissue engineering.
April 2013 in “The FASEB journal” This study observed that Platycarya strobilacea S. et Z. extract enhanced hair growth and improved hair follicle length and immune response in mice compared to control groups.