226 citations
,
February 1999 in “British Journal of Dermatology” This study reported that a treatment regimen of oral rifampicin and clindamycin for 10 weeks effectively managed folliculitis decalvans, with most patients experiencing no recurrence after one or multiple courses.
225 citations
,
April 2018 in “Journal of Investigative Dermatology” Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.
191 citations
,
November 1959 in “Annals of the New York Academy of Sciences” This article reports electron microscope studies on the structure of hair and wool, but it does not present new clinical findings.
130 citations
,
August 2015 in “Experimental Dermatology” This review provides a comprehensive guide to serum-free human hair follicle organ culture methods, highlighting research opportunities, standardization efforts, and potential applications without reporting new empirical findings.
90 citations
,
June 2006 in “The American Journal of Dermatopathology” This review outlines the classification, histopathologic presentation, and pathogenetic concepts of scarring and nonscarring alopecias, reporting no new clinical results and emphasizing the need for clinicopathologic correlation.
86 citations
,
March 2018 in “ACS Biomaterials Science & Engineering” This study found that MDP hydrogel significantly accelerated wound healing and improved tissue formation in diabetic mice compared to a standard clinical hydrogel and control buffer.
44 citations
,
April 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found a significant association between reduced FGF13 levels and X-linked congenital generalized hypertrichosis, suggesting FGF13's potential role in hair follicle growth and the hair cycle.
42 citations
,
August 1995 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that RXR-alpha is strongly expressed in both normal and psoriatic human skin, suggesting it may play a role in the transition from proliferation to differentiation in epidermal keratinocytes.
34 citations
,
January 2005 in “Journal of the American Veterinary Medical Association” This study found that cyclosporine A treatment at 5 mg/kg/day may reduce inflammation and promote gland regeneration in dogs with sebaceous adenitis, though symptoms returned when treatment stopped.
32 citations
,
March 2014 in “PLOS ONE” This study demonstrates that FMOD deficiency in mice alters TGF-β ligand and receptor expression during wound healing stages, leading to delayed wound closure and increased scar size.
30 citations
,
February 1994 in “Journal of Cutaneous Pathology” This case study highlights that breast cancer may present as alopecia refractory to usual treatments, indicating the need for consideration of underlying malignancy in such cases.
28 citations
,
August 2018 in “Dermatologic Clinics” This article discusses various aspects of trichoscopy for diagnosing hair and scalp disorders and reports no clinical results, offering guidance and highlighting pitfalls for better application of this tool by dermatologists.
28 citations
,
February 2010 in “British journal of dermatology/British journal of dermatology, Supplement” This article reviews phenotypic variability linked to WNT10A nonsense mutations and does not present new research findings.
27 citations
,
December 2002 in “Journal of dermatological science” This study demonstrated a close anatomical relationship between Merkel cells and Langerhans cells in human hair follicles, suggesting potential functional interactions in the bulge area.
27 citations
,
April 1998 in “American Journal of Dermatopathology” This study found no significant difference in estrogen and progesterone receptor expression between androgenic alopecia and alopecia areata, suggesting an indirect hormonal influence on androgenic alopecia.
26 citations
,
April 2011 in “Skin Research and Technology” This study found that in vivo confocal scanning laser microscopy accurately quantifies neogenic hair follicles in mice, producing results similar to histology while avoiding fixation artifacts.
21 citations
,
April 2019 in “Journal of cutaneous pathology” This study found a significant reduction in Treg cell frequency in alopecia areata compared to other autoimmune and non-autoimmune skin diseases using immunohistochemical staining.
21 citations
,
December 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrates that T-cell responses in extensive alopecia areata scalp may be aberrantly regulated, with reduced cytokine production but activated phenotype, providing insight into the disease's immune mechanisms.
21 citations
,
November 1969 in “Journal of Investigative Dermatology” In this study, researchers standardized the Koelle and Friedenwald technique as modified by Gomori to reliably demonstrate discrete enzyme localization around eyebrow hair follicles in humans.
17 citations
,
August 2018 in “BMC Genomics” The researchers found that HOXC13 regulates different keratin proteins in a mixed manner, with certain SNPs impeding this regulation, while also demonstrating negative-feedback by HOXC13 and positive regulation by LEF1 and melatonin on the HOXC13 promoter.
14 citations
,
May 2022 in “Animals” This study found that female Holdobaggy goslings have higher melanin content in their dorsal plumage than males, suggesting that initial plumage color can be used for sex identification.
14 citations
,
July 2016 in “Anatomical Science International” This study revealed that in androgenic alopecia, the proximal attachment of the arrector pili muscle to the hair follicle is often lost or significantly reduced.
14 citations
,
August 2004 in “Veterinary Dermatology” In this study, a thoroughbred mare exhibited a unique case of alopecia areata with lymphocytic infiltration at both the bulbar and isthmic levels of hair follicles.
13 citations
,
June 2013 in “Actas Dermo-Sifiliográficas” This review details five cases of syphilitic alopecia, an uncommon symptom in syphilis affecting mainly men, emphasizing that dermatologists should be vigilant as it can appear as the sole symptom.
13 citations
,
February 2007 in “British Journal of Dermatology” EF and PXE not closely related.
12 citations
,
January 2014 in “Cell structure and function” This study suggests that specific combinations of human type I and II hair keratins, particularly K35-K85 and K36-K81, have distinct in vitro assembly properties that are significant for macrofibril formation.
11 citations
,
June 2012 in “Acta histochemica” This study found that Gsdma3 mutations in mice led to thicker skin and longer hair infundibula, possibly by negatively regulating β-catenin expression in the epidermis.
10 citations
,
December 2018 in “Medical Science Monitor” This study suggests that the MAPK/ERK signaling pathway plays a role in the regulation of cell proliferation, apoptosis, and cycling in rat urethral plate fibroblasts affected by finasteride-induced hypospadias.
9 citations
,
February 2018 in “Journal of The American Academy of Dermatology” This study found that methylene blue staining helped identify late catagen and telogen hair follicles more accurately than unstained follicles, which suggests that established telogen percentage standards may be overestimated.
8 citations
,
February 2016 in “The American Journal of Dermatopathology” In this study, the researchers found that transplanted hair follicles undergo significant morphological changes, including a thickened dermal sheath and increased hair shaft diameter, which are associated with altered follicular vascularization.