Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses strategies for developing semi-solid topical generic products to match the quality of reference-listed drugs, using concepts like quality by design and reverse-engineering, but reports no new results.

This review found that anti-aging peptides show promise in cosmeceuticals due to their targeted actions to rejuvenate skin, but challenges like peptide stability, penetration, and limited clinical data limit their current effectiveness.

This study developed a leakage-resistant machine learning framework for classifying hair loss types, emphasizing transparency through explainable AI. Among tested models, Extreme Gradient Boosting excelled, achieving high accuracy and stability on both cross-validation and holdout datasets.

The researchers reported that PEG-FGF2 conjugates, particularly Compound 6, significantly enhanced stability, proliferation, migration, and wound healing activity compared to native FGF2, despite some reduction in bioactivity near crucial binding domains.

This review explores research on nanoformulations for enhancing the topical delivery of herbal medicines, noting potential benefits like improved bioavailability and sustained delivery, and emphasizes the need for safety and toxicity guidelines in developing these novel drug delivery systems.

This study reports the first familial case of alopecia linked to a novel homozygous variant in the DSP gene, which did not coincide with heart abnormalities despite prior associations.

This study reports the crystallization of the human androgen receptor's ligand-binding domain with nonsteroidal ligands, which may aid in understanding the differences in binding compared to steroidal ligands.

This critique of a 2019 study highlights the potential of a liposomal hydrogel for delivering Minoxidil and Tretinoin to treat androgenetic alopecia, but underscores the need for in vivo trials and further stability and interaction analysis to validate its promise.

This study's molecular dynamics simulations suggest that electrostatic interactions mainly stabilize peptide binding to human hair keratin, with the protein's dielectric constant significantly affecting free energy calculations.

In this observational study, treatment with oral isotretinoin was reported to stabilize hair loss in patients with frontal fibrosing alopecia, offering potential guidance for clinicians on its therapeutic use, with implications for improving affected patients' self-esteem.

This review discusses the potential of nanostructured lipid carriers to improve herbal treatments for alopecia and reports no new clinical results, highlighting the need for further clinical trials and safety data.

This study investigated improving Finasteride's water solubility using trimethyl-β-cyclodextrin (TM-β-CD) and β-cyclodextrin (β-CD) as carriers, finding that β-CD improved Fin's cumulative release, while TM-β-CD enhanced its solubility, with computational data supporting these outcomes.

This study used Density Functional Theory-based computational methods to analyze finasteride's molecular properties, finding that the GGA/PW91 method closely matches experimental data for vibrational frequencies and geometric parameters.

The incidence of cutaneous B-cell lymphoma increased significantly but stabilized around 2003.

This study identified ten key magistral dermatological formulations, such as personalized trichological preparations and Kligman’s formula, which fill critical gaps unmet by standardized products, particularly in cases like pediatric scabies or autoimmune mucosal diseases, illustrating the role of compounding in precision medicine.

This review discusses the application of liposomes in dermatology, highlighting their therapeutic value for drug stabilization, skin penetration enhancement, and treatment of hair follicle-associated disorders, but reports no new clinical results.

This review examines the main absorption sites and influencing factors for orally administered drugs, highlighting variables such as solubility and gastrointestinal conditions that affect drug absorption in the small intestine and the development of effective drug delivery systems.

This paper discusses the recent advancements and challenges of flexible bioelectronics in personalized health management and cancer therapy, but reports no new studies or results.

This review highlights how utilizing unconventional and non-traditional cell sources for cultivated meat production could overcome manufacturing challenges, with distinct biological advantages potentially improving bioprocess efficiency and enabling the creation of novel meat products, according to the authors.

This review outlines the potential of soft bioelectronics in wound care, emphasizing their ability to monitor and manage wounds through integrated smart systems and identifying challenges for future advancements in the field.

This study reviews the therapeutic applications and evidence around punch-based dermatologic techniques, highlighting their varying effectiveness and precision across different conditions, but emphasizes the need for further standardized research.

This study developed caffeine-loaded nanoparticles coated with ultradeformable liposomes for better hair follicle delivery, showing non-cytotoxicity and potential to reduce oxidative stress in DHT-damaged cells, suggesting an alternative treatment for androgenetic alopecia.

This study found that creambath preparations with waru leaf extract accelerated hair growth in New Zealand White rabbits, though none matched the positive control; the 37.5% concentration increased hair weight effectively.

This narrative review examined the potential of hibiscus leaves and apple skin as natural ingredients for hair tonics and reported their effectiveness in addressing hair loss, highlighting properties like strong antioxidant content and ability to strengthen hair roots.

This study found that ritlecitinib, approved for alopecia areata in patients aged 12 and older, has an acceptable safety profile with mild to moderate side effects and no increase in serious adverse events compared to placebo.

This review discusses the possible immune-mediated and environmental factors contributing to frontal fibrosing alopecia but reports no new clinical findings, emphasizing the need for standardized treatment evaluations.

This article reviews treatment options for androgenetic alopecia and suggests minoxidil 5% for early-stage women and either minoxidil or finasteride for men, without new study results.

In this study, researchers reported that topical nanostructured lipid carriers containing tea seed or lavender oil significantly enhanced hair regrowth in female Wistar albino rats over 30 days compared to placebo, with increased hair length and follicular density observed.

This study in female Wistar albino rats found that Pluronic F127-stabilized nanostructured lipid carriers with tea seed or lavender oil significantly increased hair regrowth and follicular density compared to placebo, showing enhanced efficacy over a commercial product in promoting hair growth.

This study found that somatosensory axons innervating Merkel cells in adult mouse skin exhibit significant plasticity, influenced by epithelial and neural factors, indicating a complex interaction in maintaining homeostasis.