Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that small proline-rich proteins modify the biomechanical properties of cornified cell envelopes in rodent forestomachs, potentially affecting the tissue's ability to withstand mechanical stress.

This article outlines the rationale, design, major findings, and updated objectives of the ongoing Rotterdam Study, without presenting new research data.

This review summarizes how genetic studies using conditional β-catenin loss- and gain-of-function mice have advanced understanding of canonical Wnt signaling's role in embryonic development, adult stem cell maintenance, and cancer modeling.

This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.

This study found that mutations in phosphorylation sites on the PIN3 protein disrupt its phosphorylation and subcellular trafficking, affecting auxin transport and root growth in a cell-type-specific manner.

This review discusses the role and interactions of the calcium-binding protein S100A6 in cellular processes and its association with various diseases, highlighting the need for further research to fully understand its biological impact.

This review discusses the roles of the hairless (HR) protein as a corepressor, particularly its impact on RORα-mediated transcriptional repression, and reports no new experimental findings.

In this study, the researchers developed a biomimetic multilayer composite scaffold combining a decellularized amniotic membrane, fibroblast-laden collagen gel, and epidermal stem cells, which healed full-thickness skin wounds more quickly and effectively by regenerating hair follicles without scarring compared to Moropicin ointment.

This study observed that dandruff in Indian women is associated with a distinct scalp microbiome, including specific bacterial and unknown Malassezia species, with implications for nutrient homeostasis and cell-host adhesion pathways.

This study found that Ecklonia cava extract increased skin hydration and decreased redness, suggesting potential benefits for protecting and repairing scalp skin from pollutant-induced damage.

This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.

In this study, researchers observed that EGFR deficiency in the epidermis affects gene expression related to cell differentiation and structure, highlighting spatial and temporal roles of EGFR during skin and hair follicle development.

In this study, researchers found that disrupting desmoglein 3 signaling in a mouse model of pemphigus vulgaris activates normally quiescent hair follicle stem cells, compromising their multipotency but prompting a regenerative response that restores stem cell function and structures.

In this study, researchers found that the cell surface protein Lrig1 plays a crucial role in regulating the suppressive function of regulatory T cells, suggesting it as a potential target for treating autoimmune diseases, as evidenced by experiments in mouse models.

This perspective review discusses the crucial role of the stem cell niche in influencing stem cell function and its potential as a target for developing new regenerative medicine strategies, but reports no new clinical results.

This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.

This review highlights the crucial role of vitamin D signaling in epidermal stem cells during skin wound healing, emphasizing its distinct functions from calcium metabolism and its importance in genomic regulation mediated by the vitamin D receptor.

Low-Level Laser Therapy can stimulate healing and cell function, potentially leading to wider medical use.

This review provides a comprehensive overview of melatonin's physiological roles, effects, and clinical implications, but it does not present new experimental findings.

This review explains the mechanical composition and molecular interactions that determine hair's mechanical properties, without providing any new experimental findings.

This study found that RSPO1, a Wnt/β-catenin pathway agonist, significantly induces insulin-producing β cell replication and neogenesis in various settings, offering a promising potential therapy for diabetes.

This review discusses the role of the BAFF system in autoimmune diseases and highlights its therapeutic potential, emphasizing the need for disease-specific clinical trials to improve treatment strategies.

This review discussed the potential of induced pluripotent stem cells (iPSCs) for hair follicle regeneration, covering current approaches and challenges, iPSC differentiation, and their possible future clinical applications in hair restoration.

This study found that the loss of Msx2 in knockout mice led to phenotypes similar to Peters anomaly and microphthalmia, suggesting that MSX2 plays a critical role in anterior segment development of the eye.

This study evaluated a new composite material made from PLA, ALG, ZnS, and HT for blood-contacting applications, finding it improved surface characteristics and displayed anticoagulant properties and high biocompatibility with no genotoxic effects on blood and skin cells.

This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.

This review highlights that vitexin, a natural flavonoid derived from plants like mung bean, modulates critical cellular processes involved in cancer progression, suggesting its potential as a multi-target anticancer treatment in preclinical studies.

This review discusses the therapeutic potential of MSC-derived secretomes for treating degenerative and inflammatory diseases, reporting no new clinical results but highlighting their proposed mechanisms and advantages over direct MSC transplantation.

This study suggests that Staphylococcus capitis ferment filtrate (SCFF) may promote hair growth and scalp health by modulating pathways related to hair loss, aging, and oxidative stress in vitro.

This review outlines how peptidyl arginine deiminases (PADIs) and protein citrullination are involved in hair follicle regeneration and inflammatory alopecia, but presents no new clinical findings.