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Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Gene mutations can cause problems in male genital development.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Androgen treatment with dihydrotestosterone may help maintain height in patients with 5-α-reductase type 2 deficiency, especially before puberty.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

A certain mutation in the fetal alpha 5-reductase gene is linked to a higher risk of late miscarriage.

The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

Longer TA repeats in the SRD5A2 gene may increase acne risk in Chinese people.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Researchers found a new ABCD1 gene mutation linked to a rare brain and nerve disorder with unusual brain changes.

The gene for slick hair in Senepol cattle is located on chromosome 20 and may involve the SRD5A2 gene.

Scientists have created a new hair loss treatment using ultrasound to deliver gene-editing particles, which resulted in up to 90% hair regrowth in mice.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Genetic variations greatly affect individual metabolism and can impact health and disease risk.

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Genes and hormones cause hair loss, with four genes contributing equally.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

The document suggests more research is needed to understand the link between baldness and prostate cancer.