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Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.

Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.

Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

Skin stem cells are maintained by signals from nearby cells and vary in their ability to renew and mature.

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.

Adult skin cell-based early-stage skin substitutes improve wound healing and hair growth in mice.

A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.

Human dermal fibroblasts help microvascular endothelial cells grow, but not vice versa.

Topical treatments can deliver active molecules to skin stem cells, potentially helping treat skin and hair disorders, including skin cancers and hair loss.

Scientists created early-stage hair follicles from human skin cells, which could help treat baldness and study hair growth.

The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.

Keratinocytes and adipose-derived stem cells can effectively heal difficult skin wounds.

The exact identity of skin stem cells and how skin cells differentiate is not fully known.

Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.

Obesity can weaken the skin's ability to fight infections because fat cells stop and reduce the infection-fighting properties of nearby stem cells.

Stem cells regenerate tissues and their behavior varies by environment, suggesting the hematopoietic system model may need revision.

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

Human hair follicle dermal cells can effectively replace other cells in engineered skin.

Calcium is important for stem cell function and maintenance, especially in blood and skin cells.

Gene network oscillations inside hair stem cells are key for hair growth regulation and could help treat hair loss.

Epidermal stem cells have various roles in skin beyond just maintenance, including forming specialized structures and aiding in skin repair and regeneration.

Nestin-expressing cells turn into a specific type of skin cell in hair follicles during development and in adults.

Dermal stem cells help regenerate hair follicles and heal skin wounds.

Stem cell self-renewal is complex and needs more research for full understanding.

Hair follicle stem cells help skin heal and grow during stretching.

Aging reduces skin stem cell function, leading to changes like hair loss and slower wound healing.