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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Finasteride doesn't effectively treat hair loss in postmenopausal women.

Androgen deprivation therapy for prostate cancer can cause sexual, physical, and psychological side effects, and doctors should manage these carefully.

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

The Rotterdam Study aims to understand various diseases in older adults.

Sorafenib is effective in treating Desmoid Tumor/Deep Fibromatosis.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Sulforaphane from broccoli can help protect skin from sun damage.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Fibromodulin might help reduce scarring if increased in adult wounds like in fetal skin that heals without scars.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Stem cell niches support, regulate, and coordinate stem cell functions.

Radiation therapy with a higher dose for the brain improves survival in cerebellar medulloblastoma.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Bioprinting could improve wound healing but needs more development to match real skin.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

Some drugs can cause hair loss or increase hair growth, but these effects are usually reversible when the drug is stopped.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Minoxidil shortens baldness from chemotherapy by 50.2 days without significant side effects.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

Low-oxygen conditions and ECM degradation products increase the healing abilities of perivascular stem cells.

Platelet-rich plasma might help tissue regeneration in dentistry, but results vary and more research is needed.

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.

Children with loose anagen hair have easily pluckable hair due to root sheath problems, and it might improve without treatment.

Despite progress, better treatments and understanding are needed for the high rates of long-term issues and deaths linked to eating disorders.

5% minoxidil helps hair regrowth in androgenic alopecia.