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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Dutasteride more effective for hair growth, but has more side effects than finasteride.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Androgens can both increase and decrease hair growth in different parts of the body.

Oestrogens are key for bone growth during puberty in both boys and girls.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

Trilostane effectively improved symptoms in dogs with a certain adrenal gland disorder.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Allergic reactions to blood thinners are rare but can be serious, requiring careful testing and alternative treatments.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Finasteride effectively treats baldness but may cause sexual side effects.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

The document concludes that proper diagnosis and a multidisciplinary approach are crucial for managing Congenital Adrenal Hyperplasia effectively.

Finasteride effectively treats hidradenitis suppurativa for most patients.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

Mouflon rams mature gradually with changes in body, horns, and hormones linked to age and seasons, reaching full sexual maturity well after puberty.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.