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The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Gene mutations can cause problems in male genital development.

Some patients may experience lasting sexual dysfunction, depression, and other side effects from 5α-reductase inhibitor therapy.

Saw palmetto can help with prostate issues and may promote hair growth.

The document covers various male health issues, their causes, treatments, and related conditions.

The foreword introduces a medical issue discussing male hormonal health, treatments, and the effects of conditions like obesity and aging.

A new TP63 mutation was found in a baby with EEC syndrome, showing the need for TREC testing to check for immune issues.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.

Fatty acid transport protein 4 is essential for skin and hair development.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

Mouflon rams mature gradually with changes in body, horns, and hormones linked to age and seasons, reaching full sexual maturity well after puberty.

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.

Researchers found 15 new genetic links to skin traits in Japanese women.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Reduced AR gene methylation may cause early pubic hair growth in girls.

The document concludes that Nonclassic Congenital Adrenal Hyperplasia requires personalized treatment plans to manage symptoms and fertility, with glucocorticoids being a common therapy.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Longer CAG repeat lengths in the androgen receptor gene are linked to higher testosterone levels in women with PCOS.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

Finasteride may cause sexual side effects like erectile dysfunction, but they are reversible and affect less than 2% of men.