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Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Dutasteride more effective for hair growth, but has more side effects than finasteride.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Androgens can both increase and decrease hair growth in different parts of the body.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Oestrogens are key for bone growth during puberty in both boys and girls.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Stem cell niches support, regulate, and coordinate stem cell functions.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Trilostane effectively improved symptoms in dogs with a certain adrenal gland disorder.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Allergic reactions to blood thinners are rare but can be serious, requiring careful testing and alternative treatments.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Finasteride effectively treats baldness but may cause sexual side effects.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Oral retinoids are effective for various skin conditions but have side effects and should not be used during pregnancy.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

The document concludes that proper diagnosis and a multidisciplinary approach are crucial for managing Congenital Adrenal Hyperplasia effectively.