Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, spearmint tea significantly reduced testosterone levels and improved self-reported hirsutism in women with PCOS, but did not change objective hair growth scores over the short trial period.

This review suggests spearmint tea may lower androgenic hormones in women with hirsutism and related symptoms, though longer treatment and follow-up may be needed for noticeable improvements.

This article reviews the regulation and roles of spermidine/spermine-N(1)-acetyltransferase (SSAT) in polyamine metabolism and its potential as a target in cancer and other diseases, without reporting new experimental results.

This study found that overexpression of the enzyme spermidine/spermine N1-acetyltransferase in mice was associated with increased fat oxidation and a leaner phenotype, while knock-out mice exhibited increased fat accumulation.

This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.

This study found that transgenic mice overexpressing the SSAT gene under a metallothionein promoter suffered delayed hair loss and were highly sensitive to polyamine analogues, which led to significant liver changes and mortality.

In this study, transgenic mice overexpressing the SSAT gene were highly sensitive to polyamine analogues, leading to severe liver changes and high mortality rates after treatment.

This study observed that applying polyamines to the skin of hairless mice stimulates thymidine incorporation, suggesting polyamines may play a role in DNA synthesis control in the epidermis.

This study observed varying levels of polyamines in different compartments of rat hair follicles, indicating their potential involvement in hair growth, especially in the matrix and inner root sheath layers.

In this study, Sper-12/siRNA nanoparticles effectively suppressed abnormal AR protein levels, promoted hair follicle proliferation, and alleviated hair loss symptoms in androgenetic alopecia model mice, providing a promising delivery platform for siRNA-based therapeutics.

This study suggests that activation of polyamine catabolism in K6-SSAT transgenic mice may significantly increase skin tumor development and progression to carcinomas following chemical induction.

This study suggests that increased putrescine levels may disrupt normal hair follicle development in transgenic mice, leading to hair loss and altered skin structure, yet these mice appear more resistant to skin tumorigenesis.

This research suggests that defects in keratinocyte differentiation due to putrescine accumulation in SSAT transgenic mice lead to skin changes and hair loss, and reducing putrescine can promote hair regrowth.

This review discusses the clinical use of anti-androgen medications and highlights emerging evidence supporting plant-derived anti-androgens like spearmint tea for managing PCOS, but reports no new clinical results.

In this study, researchers used molecular docking analysis to explore the potential of spearmint's phytochemicals in managing PCOS, identifying oleanolic acid as having the best binding affinity with proteins associated with the condition. However, these results are computational and require further laboratory experiments for validation.

In this study from IJIRT, researchers evaluated teaching programs focused on enhancing waste management knowledge among women, assessing the effectiveness of these educational initiatives.

This study found that administering an alcoholic extract of Mentha spicata leaves significantly reduced testosterone levels and aggressive behavior in female rats with elevated testosterone, suggesting its potential protective role against such symptoms.

This review reported that various herbs including cinnamon, fenugreek, and turmeric may effectively treat polycystic ovarian disorder with minimal side effects, suggesting potential for herbal therapies to target the disorder's root causes and improve overall health.

This review explores plant-based pharmacological advances for treating polycystic ovary syndrome, reporting no new clinical results but highlighting potential benefits for menstrual cycle regulation and testosterone reduction.

This article reviews existing strategies for managing polycystic ovarian disease and highlights the role of lifestyle changes, natural remedies, and conventional treatments, reporting no new clinical results.

This review covers the diagnosis, complications, and management strategies for Polycystic Ovarian Disease, reporting no new clinical results and highlighting the potential of personalized medicine.

This study explored treatment options used by women with PCOS and found that many prefer lifestyle modifications and alternative therapies like low-carb, high-protein, or low-calorie diets alongside supplements such as vitamin D, spearmint tea, omega-3s, and probiotics, often in addition to prescription medications like Metformin.

This review discusses the management of polycystic ovary syndrome and highlights the benefits of an integrative approach combining lifestyle, pharmacological, and herbal treatments, but reports no new research findings.

This study found that overexpression of the enzyme SSAT in a mouse model significantly reduced prostate tumor size and progression, suggesting it could be a promising strategy against prostate cancer.

This study found that spermidine, a polyamine, plays an essential role in hair growth in sheep follicles, while spermine is not required for normal follicle function.

This article reviews the role of polyamines in hair follicle growth and discusses potential therapeutic applications but provides no new clinical results.

This article describes the synthesis of novel polyamine-modified minoxidil analogs and conjugates to potentially enhance minoxidil's biological activity, selectivity, and water solubility, but reports no new biological results.

This study reports that patients with Alzheimer's disease have increased levels of polyamines in their hair.

This study reported that certain minoxidil conjugates, specifically those with spermine, methylenedianiline, and diaminofluorene, were able to induce differentiation in HL-60 acute myeloid leukemia cells without toxicity at a concentration of 10 μM.

In this study, Rahim et al. found that keratinocyte differentiation requires changes in polyamine ratios mediated by AMD1, suggesting that targeting polyamine availability could be useful for treating hyperproliferative skin disorders.