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    Glossary Spatial Transcriptomics

    Spatial transcriptomics is a cutting-edge technique that allows researchers to map gene expression within tissue samples while preserving the spatial context of the cells. This method is particularly relevant to hair loss and hair biology as it enables the study of the molecular mechanisms underlying hair follicle development, cycling, and pathology in a spatially resolved manner. Key distinguishing characteristics include the ability to visualize the distribution of RNA transcripts in situ, providing insights into how different cell types interact and contribute to hair growth or loss. This technology holds promise for identifying novel therapeutic targets for hair loss conditions.

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    Research 30 of 1000+

    1. Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla 2022 · 10 citations
    2. Deconvolving organogenesis in space and time via spatial transcriptomics in thick tissues 2024 · 3 citations
    3. Spatial transcriptomics reveals asymmetric cellular responses to injury in the regenerating spiny mouse (<i>Acomys</i>) ear Genome research · 2023 · 1 citations
    4. Spatial transcriptomics of a giant pilomatricoma Journal of cutaneous pathology · 2023 · 1 citations
    5. 463 Spatial transcriptomics reveals an inflammatory profile in photoexposed light skin, which is absent in dark skin Journal of Investigative Dermatology · 2025
    6. 0034 Cross-species insights into hair follicle-T cell interactions in discoid lupus erythematosus: A comparison of human, canine and mouse models using spatial transcriptomics Journal of Investigative Dermatology · 2025
    7. 0952 Spatial transcriptomics reveal compartmentalized dysregulation of lipid metabolism in acne vulgaris Journal of Investigative Dermatology · 2025
    8. Single-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopecia Cell & Bioscience · 2025
    9. Comparative spatial transcriptomics of hair follicle-T cell interactions in mouse, dog and human reveals conserved drivers of primary cicatricial alopecia bioRxiv (Cold Spring Harbor Laboratory) · 2025
    10. Disturbance of Immune Microenvironment in Androgenetic Alopecia through Spatial Transcriptomics International Journal of Molecular Sciences · 2024
    11. Protocol for preparing mammalian skin samples encompassing hair follicles for spatial transcriptomics STAR Protocols · 2024
    12. LB881 Unraveling mechanisms of scarring alopecia in discoid lupus: Insights from spatial transcriptomics Journal of Investigative Dermatology · 2024
    13. 1619 Spatial transcriptomic analysis of imiquimod-treated mouse skin reveals deregulation of lipid raft-associated markers which could be reversed by re-introduction of caveolin scaffolding domain peptide Journal of Investigative Dermatology · 2023
    14. Single‐cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts Experimental Dermatology · 2020 · 35 citations
    15. Spatial and single-cell transcriptomics unravel the complex interplay between the body and medical implants Cell Biomaterials · 2025 · 10 citations
    16. 464 Spatial transcriptomics links gene expression profiles to functional and structural traits of darkly pigmented skin Journal of Investigative Dermatology · 2025
    17. Cross-species comparative spatial transcriptomics of hair follicle-T cell interactions identifies conserved drivers of cutaneous lupus erythematosus skin disease and associated hair loss Nature Communications · 2026
    18. 189 Integrating single-cell and spatial transcriptomics of human hair follicles to define transcriptional signature of follicular dermal papilla 2022
    19. MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis Scientific Reports · 2025 · 12 citations
    20. Molecular and spatial landmarks of early mouse skin development Developmental cell · 2023 · 10 citations
    21. 1376 A multi-scale spatial atlas of human skin links cancer cell states to site of origin Journal of Investigative Dermatology · 2023
    22. Exploring machine learning strategies for single-cell transcriptomic analysis in wound healing Burns & Trauma · 2025 · 5 citations
    23. 220 Dynamic and spatial transcriptional responses in COVID-19-related chilblains Journal of Investigative Dermatology · 2023
    24. Advances and applications of biomimetic biomaterials for endogenous skin regeneration Bioactive Materials · 2024 · 23 citations
    25. Organoid‐Guided Precision Medicine: From Bench to Bedside MedComm · 2025 · 17 citations
    26. Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats Frontiers in Veterinary Science · 2025 · 2 citations
    27. Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis JCI Insight · 2025 · 1 citations
    28. Human relevant platforms for cutaneous wound healing research: current landscape, translational gaps, and emerging frontiers Frontiers in Bioengineering and Biotechnology · 2026
    29. Gli2-serpinh1 drives fibroblast state transition during skin wound healing npj Regenerative Medicine · 2026
    30. Multimodal Human Scalp Atlas Defines Cell Landscape and Lineage Architecture In Situ bioRxiv (Cold Spring Harbor Laboratory) · 2026