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Early and late matrix progenitors in hair follicles create different cell layers, with early ones forming the companion layer and later ones forming the inner root sheath and hair shaft.

Sweat glands and hair follicles are determined by opposing signals, with BMPs promoting sweat glands and blocking BMPs leading to hair follicles.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

Applying a special compound can promote hair growth without harmful side effects.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

Hedgehog signaling is crucial for mammary gland development over hair follicles.

Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.

Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.

The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

Hes1 protein is important for hair growth and regeneration, and could be a potential treatment for hair loss.

New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.

XIST RNA helps regenerate hair follicles by targeting miR-424 and activating hedgehog signaling.

HPV genes and estradiol increase a cancer-related signaling pathway, which may be targeted for cervical cancer treatment.

COX2 and ATP synthase control the size of hedgehog spines.

The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.

LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.

Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.

Cancer treatments can cause hair loss, but it is often reversible and can be managed with scalp cooling and support.

The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.

Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.

β-Catenin is essential for new hair growth after skin injury.

Understanding and managing side effects of hedgehog pathway inhibitors can improve treatment for advanced basal cell carcinoma.

Hedgehog pathway inhibitors can treat certain aggressive cancers but face limitations like resistance and side effects.

Hedgehog signaling in certain cells is crucial for hair growth during wound healing.

Targeted therapy for skin cancer is complex due to the role of the hedgehog pathway in both cancer and hair growth.

Hedgehog signaling controls hair follicle development and can affect skin cancer growth.

Odontogenic keratocysts are caused by abnormal Hedgehog signaling and can lead to tooth and bone issues.

Hair growth-related cells need the enzyme SCD1 to help maintain the area that supports hair growth.