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New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.

Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.

Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.

The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.

LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.

Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.

Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.

Wnt proteins from certain skin cells are crucial for normal hair growth and renewal.

The proteins transthyretin and megalin are more present in the growth phase of hair, suggesting they might affect hair health and growth.

Targeted therapy for skin cancer is complex due to the role of the hedgehog pathway in both cancer and hair growth.

The HOXC13 gene affects different hair proteins in cashmere goats in varied ways and is controlled by a feedback loop and other factors.

AP-2α and AP-2β proteins are essential for healthy adult skin and hair.

COX2 and ATP synthase control the size of hedgehog spines.

SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.

Early-stage skin cells help regenerate hair follicles, with proteins SDF1, MMP3, biglycan, and LTBP1 playing key roles.

Dentin sialoprotein and phosphophoryn are present in rodent hair follicles and may help hair growth and development.

Deleting the EDAR gene in Cashmere goats affects genes and proteins related to hair growth.

Abnormal gene expression related to keratin causes hair loss in certain mice.

Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.

Damaged hair follicles make mice more prone to skin inflammation and skin cancer after UV exposure.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.

Intu gene is crucial for hair follicle formation by helping keratinocytes differentiate through primary cilia.

Rat dermal papilla cells have unique genes crucial for hair growth.