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The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Dextran sulfate was found to be toxic and ineffective for treating HIV.

Hair follicles may soon be used more for targeted and systemic drug delivery.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Modern science supports the use of some Ayurvedic plants for health, as ancient practices suggested.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

Silver nanoparticles coated with substances like PEG showed strong antibacterial effects and improved wound healing when used in hydrogels.

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

Hair analysis can detect cocaine use but doesn't accurately show the amount or timing of use.

Taking selenium supplements during chemotherapy may help reduce side effects and improve health markers in ovarian cancer patients.

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

No single treatment is consistently effective for alopecia areata, and more research is needed.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

Platelet-rich plasma might help with hair growth and skin conditions, but more research is needed to prove its effectiveness and safety.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.