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In this study, curcumin-loaded nanoparticles with a size of 400 nm showed optimal accumulation in human hair follicles after seven days, although mouse models differed significantly in penetration and retention, indicating limitations in their suitability for follicular drug delivery studies.

This review discusses the progress and challenges in delivering CRISPR/Cas9 systems for in vivo genome editing, highlighting current methods and opportunities for future therapeutic applications.

This review paper highlights the development and application of organic and biogenic nanocarriers for delivering bioactives, focusing on eco-friendly and sustainable nanotechnology strategies while addressing challenges like toxicity and paving the way for future innovations in green solution approaches.

This review highlights the potential of nanotechnology-based formulations in hair care and treatment, emphasizing how these innovative materials can enhance the stability, efficacy, and safety of active compounds while addressing the limitations of conventional formulations.

This review highlighted recent advances in nanocarrier-based topical delivery systems for skincare, emphasizing their potential to enhance ingredient stability, penetration, and targeted release while addressing specific pathophysiological skin concerns.

This review highlights the potential of nanotechnology for hair follicle regeneration, focusing on strategies such as hair cycle modulation, progenitor cell stimulation, and wound-induced hair neogenesis, while also discussing regulatory challenges that may affect the development of these innovative approaches.

This review study focused on various in vitro methods to evaluate skin permeation and retention of sunscreens, highlighting the importance of assessing sunscreen penetration due to widespread nanomaterial usage and advancements in cosmetic formulation.

This review discusses the mechanisms involved in wound healing and explores the potential of nanomaterials as a promising approach to managing chronic wounds, but reports no new clinical findings.

This review discusses the use of nanocarrier technology in functional cosmetics to enhance skin penetration, increase ingredient stability, and allow codelivery of active ingredients, without reporting new clinical results.

This review article highlights how hair follicle-targeting drug delivery systems enhance therapeutic outcomes and reduce side effects for treating conditions like androgenetic alopecia and acne vulgaris. The authors discuss current formulations and evaluate their performance in both preclinical and clinical settings.

This review outlines recent advancements in droplet-based microfluidics used with food-grade materials to create delivery systems, emphasizing the design and function of systems like emulsions and microcapsules while discussing challenges related to scaling these processes from lab to industry.

This paper reviews the development of transdermal drug delivery systems for skin diseases, from first to fourth generation, and highlights ongoing challenges and the importance of clinical trials, but provides no new clinical results.

In this study, researchers developed topical tofacitinib-loaded cationic lipid nanoparticles, which improved absorption and targeted hair follicles in an ex vivo pig ear model, showing promise in treating alopecia areata by reducing symptoms through the JAK/STAT pathway.

This study suggests that combining scalp cooling with resveratrol-loaded nanoparticles effectively protects hair follicles from chemotherapy-induced damage, highlighting a potential method to prevent hair loss during cancer treatment.

In this study, researchers developed a novel gel formulation combining zinc oxide nanoparticles and finasteride-loaded nanostructured lipid carriers, which showed promising results for topical delivery and effective skin penetration, potentially offering a new treatment approach for androgenic alopecia.

This study explored using a chitosan oligomer coating for topical delivery of dutasteride-loaded nanostructured lipid carriers, aiming to reduce systemic exposure and cytotoxicity.

This study found that actively targeted AN2728-loaded nanocarriers reduced inflammation and improved skin condition in a mouse model of psoriasiform inflammation compared to free drug and non-targeted nanoparticles.

This review discusses how polymer- and lipid-based nanostructures can enhance wound healing by addressing issues like microbial contamination and inflammation, though it reports no new clinical results.

This review discusses recent advances in skin penetration mechanisms, specifically focusing on the enhanced understanding of the follicular pathway and its implications for transdermal therapies, immune system targeting, and nanoparticle safety.

In this review, researchers discussed recent advances in nanotechnology for topical skin applications, highlighting how nanocarriers enhance skin penetration and targeting in treatments for diseases like melanoma and psoriasis, while acknowledging that the penetration mechanisms and health impacts of nanoparticles remain not fully understood.

This review discusses various nanotechnology-based strategies for managing melasma and reports no new clinical results, highlighting the potential of innovative drug delivery systems in treating hyperpigmentation.

This review highlights recent advances in the design of nanocarrier systems for transdermal drug delivery, detailing their potential to improve treatment precision for dermatologic conditions despite challenges like formulation stability and scalability.

In this review, researchers introduced clinically tunable siRNA delivery systems for hair loss treatment, discussing design principles and analyzing relevant clinical trials to propose a framework for optimizing siRNA delivery in a clinical context.

This review discusses the potential of nanocarriers to enhance transdermal drug delivery and the combination of these carriers with physical methods, but it reports no new experimental results.

This article reviews recent developments in microneedles combining metallic elements and herbal compounds for wound healing, highlighting their benefits such as enhanced therapeutic efficacy and reduced toxicity, and offering a reference for future advancements in this technology.

This review highlights that nanotechnology shows promise in improving cervical cancer treatment by specifically targeting cancer cells, potentially enhancing treatment efficacy and reducing side effects compared to conventional therapies.

This review highlights how nanotechnology enhances CRISPR-Cas9's potential for cancer treatment by improving delivery and stability, addressing key challenges like immunogenicity and delivery inefficiencies, and discusses recent advancements in stimuli-responsive nanoplatforms for precise genome editing.

This review discusses various methods for delivering CRISPR/Cas9 for gene editing in vitro and in vivo, highlighting delivery as a major challenge but reports no new experimental results.

This study found that nano-sized lipid particles improved the skin accumulation and retention of dexamethasone compared to a base cream, suggesting potential benefits for inflammatory skin disease treatment.

This study found that nanostructured lipid carriers with more soybean phosphatidylcholine provided better skin retention and follicular targeting for diphencyprone compared to other formulations and controls.