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GlossaryValproic Acid (Sodium Valproate)

medication used to treat epilepsy and bipolar disorder

Valproic Acid, also known as VPA or by brand names like Depakote, is a medication primarily used to treat epilepsy, bipolar disorder, and to prevent migraine headaches. It works by increasing the levels of certain neurotransmitters in the brain, which helps stabilize electrical activity and mood. Additionally, Valproic Acid has been studied for its potential effects on hair growth, as it may influence pathways involved in hair follicle cycling.

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Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

research Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

19 citations, September 2020 in “Pharmaceutics”

Sodium Valproate nanospanlastics could be a safe and effective treatment for Androgenic Alopecia, with fewer side effects than minoxidil.

research Serum Drug Level-Related Sodium Valproate-Induced Hair Loss

17 citations, January 2013 in “Indian Journal of Pharmacology”

High levels of the seizure medication sodium valproate can cause hair loss.

research Sex Differences in Animal Models of Sodium Valproate-Induced Autism in Postnatal BALB/c Mice: Whole-Brain Histoarchitecture and 5-HT2A Receptor Biomarker Evidence

9 citations, January 2022 in “Biology”

Male mice are more susceptible to autism-like changes from valproic acid than female mice.

research Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System

8 citations, October 2019 in “The Journal of surgical research/Journal of surgical research”

Sodium valproate helps skin healing by affecting GABA and histone deacetylase.

research Frequency of Sodium Valproate-Induced Hair Loss and Curly Hair

6 citations, June 2005

Sodium valproate caused hair loss and curly hair in 3.5% of patients.

research Sodium Valproate-Induced Kinky Hair

4 citations, February 2001 in “PubMed”

A medication called sodium valproate likely caused a girl's hair to become kinky and dry.

research Sodium Valproate-Aggravated Psoriasiform Eruption

2 citations, September 2014 in “International Journal of Dermatology”

Sodium valproate can worsen psoriasis-like skin conditions.

research Sodium Valproate Induced Alopecia: A Case Series

1 citations, January 2017 in “Journal of Clinical and Diagnostic Research”

Sodium valproate can cause reversible hair loss in some patients.

research Dermatoprotective Effect of Moringa Oleifera Leaf Extract on Sodium Valproate-Induced Skin Damage in Rats

July 2024 in “Drug and Chemical Toxicology”

Moringa oleifera leaf extract protects skin from damage caused by sodium valproate.

Topical Sodium Valproate-Loaded Nanospanlastics Versus Conventional Topical Steroid Therapy in Alopecia Areata: A Randomized Controlled Study

research Topical Sodium Valproate-Loaded Nanospanlastics Versus Conventional Topical Steroid Therapy in Alopecia Areata: A Randomized Controlled Study

January 2024 in “Archives of dermatological research”

Both treatments for alopecia areata showed similar modest effectiveness.

research Hypertensive Urgency in a Child with Focal Epilepsy: Is It Sodium Valproate Induced?

May 2022 in “Indian Journal of Pharmacology”

Sodium valproate can cause serious high blood pressure in children.

research Using Sodium Valproate in Children Under 2 Years of Age: Study in a District Hospital, Dinajpur, Bangladesh

May 2021 in “American journal of medical sciences and medicine”

Sodium valproate caused vomiting in 20% of children under 2 years old, with other side effects like hair loss and loss of appetite also noted.

research Side Effects of Sodium Valproate Among Children With Epilepsy Under 2 Years of Age

July 2020 in “Scholars journal of applied medical sciences”

Sodium valproate caused vomiting, hair loss, loss of appetite, abdominal pain, weight gain, and anemia in young children with epilepsy.

research Curly Hair: A Rare Side Effect of Sodium Valproate in a Child

January 2019 in “Pediatric Oncall”

Sodium valproate can rarely cause curly hair in children.

research Sodium Valproate for Painful Peripheral Neuropathy in Diabetic Patients

September 2018 in “Practical diabetes”

Sodium valproate is not recommended as a first-line treatment for neuropathy but may be used in resistant cases.

research Sodium Valproate: Doctor Jekyll and Mister Hyde

August 2018 in “Online journal of neurology and brain disorders”

Sodium valproate is effective in treating epilepsy, especially in patients who don't respond to other medications.

Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation Versus Minoxidil 5% in the Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study

research Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation Versus Minoxidil 5% in the Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study

January 2023 in “The Egyptian Journal of Hospital Medicine”

Topical Valproic acid and 5% Minoxidil both significantly increase hair count in Female Pattern Hair Loss, with similar side effects.

research Side Effects of Sodium Valproate During Long-Term Treatment in Epilepsy

18 citations, January 2009 in “Acta neurologica Scandinavica”

Long-term sodium valproate treatment for epilepsy generally caused mild and temporary side effects.

Efficacy of Spironolactone as Adjunctive Therapy to Sodium Valproate in Bipolar-I Disorder: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial

research Efficacy of Spironolactone as Adjunctive Therapy to Sodium Valproate in Bipolar-I Disorder: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial

1 citations, November 2023 in “Brain and behavior”

Spironolactone improved cognitive performance and early sleep quality but not manic symptoms, appetite, or body weight in bipolar disorder when added to sodium valproate.

research Dose-Dependent Valproate-Induced Alopecia in Patients with Mental Disorders

9 citations, January 2015 in “Indian Journal of Pharmacology/The Indian journal of pharmacology”

Higher doses of the medication valproate can cause hair loss, which may stop when the dose is lowered or the medication is stopped.

research The Efficacy and Safety of Valproic Acid Medications with Controlled Active Ingredient Release in Adults in Real Clinical Practice from the Position of Pharmacokinetic and Pharmacogenetic Approaches

5 citations, January 2017 in “Nevrologiâ, nejropsihiatriâ, psihosomatika”

Sustained-release sodium valproate is effective in treating epilepsy, with some side effects influenced by genetics.

research Visual Field Defect in a Patient Given Sodium Valproate Then Carbamazepine: Possible Effect of Aminotransferase Inhibition

1 citations, April 2002 in “PubMed”

Anti-epileptic drugs may cause visual and hair side effects due to enzyme inhibition, especially in genetically predisposed individuals.

research Possible Carbamazepine-Induced Reversible Onychomadesis

13 citations, September 1989 in “International Journal of Dermatology”

Carbamazepine may cause reversible nail detachment.

research Obesity, Polycystic Ovarian Syndrome, and Thyroid Dysfunction in Women with Epilepsy

6 citations, January 2012 in “Annals of Indian Academy of Neurology”

Women with epilepsy on certain medications might gain weight and have higher thyroid-stimulating hormone levels, but not more polycystic ovarian syndrome.

research Progressively Intractable Seizures, Focal Alopecia, and Hemimegalencephaly

4 citations, May 1994 in “Neurology”

The boy had a unique condition with seizures, uneven hair loss, and an enlarged brain hemisphere.

research Cosmetic Effects of Anti-Epileptic Drugs (AEDs)

January 2024 in “Authorea (Authorea)”

Antiepileptic drugs cause cosmetic side effects like hair loss and weight gain, but patients still take their medication without it affecting their quality of life.