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This review discusses the integration of nanoparticles with microneedles to improve drug delivery through enhanced stability, bioavailability, and controlled release, noting ongoing challenges with stability, scalability, and safety.

This review provides an overview of microneedle-assisted photomedicine, detailing diagnostic and therapeutic strategies, design principles, and challenges for translating this approach to skin disease management.

This study investigated the use of dissolving microneedle patches to improve the skin-lightening effects of alpha-arbutin and resveratrol, finding that the patches enhanced intradermal delivery and slightly decreased the melanin index without affecting skin hydration or causing irritation over 24 hours.

This review discusses the development and applications of microneedles, particularly through 3D printing, highlighting their potential in transdermal drug delivery but reporting no new results.

This review highlights how advanced nanocarrier and microneedle-based transdermal drug delivery strategies can potentially improve the treatment of skin diseases by enhancing site-specific drug delivery, increasing skin penetration, and reducing systemic toxicity compared to conventional methods.

This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.

This review summarizes the application of microneedles in treating various skin diseases and highlights challenges like low drug loading, noting no new clinical results are reported.

This study reported that a magneto-responsive transdermal microneedle system delivered Minoxidil effectively and significantly increased hair density by 800% in mice with androgenetic alopecia after 10 days.

This study developed an antimicrobial microneedle patch for delivering apoptotic vesicles to treat infected wounds, which was found to effectively reduce bacterial growth and accelerate scarless healing, including the rapid formation of mature hair follicles in just 8 days, a previously unreported early outcome.

This study reports that a novel ketoconazole-loaded microneedle array significantly enhances drug delivery and retention in the skin, demonstrating improved hair growth in animal models, suggesting a promising treatment for androgenic alopecia that addresses current topical therapies' limitations.

This study reviews recent advancements in microneedles made from PLGA, highlighting their use in delivering vaccines, drugs, and proteins through the skin with minimal invasiveness, and discusses the challenges and future potential of these delivery systems.

This study demonstrated that a new topical treatment using ketotifen-loaded microneedles, designed for prolonged release, significantly reduced inflammatory markers in an animal model of allergic conjunctivitis, suggesting enhanced therapeutic delivery and sustained ocular benefits.

This review suggests that although hydrolyzed collagen peptides with certain supplements may improve skin elasticity and joint function, evidence for collagen's anti-aging and regenerative benefits remains inconsistent.

This article reviews advanced strategies for enhancing drug delivery to cutaneous stem cells to improve treatment for skin conditions and reports no new experimental findings.

This study explored the potential of silk fibroin methacrylate hydrogel microneedles to deliver α-MSH directly to the epidermis in vitiligo patients, enhancing melanocyte protection and melanosome transfer, potentially offering a new treatment avenue for this challenging condition.

This review examines the potential of swellable microneedles in drug delivery and diagnostics, highlighting innovations and challenges in their use for chronic disease treatment, but noting that issues like physiological responsiveness and long-term stability still require research.

This review examines hydrogel microneedles for transdermal drug delivery, discussing their applications and challenges but reports no new clinical results.

This review discusses the advantages, applications, and current trends of dissolving microneedles for drug delivery across various therapeutic areas and reports no new clinical results.

This review highlights the potential of microneedle technology in traditional Chinese medicine as a promising transdermal delivery system for skin diseases, showcasing improved efficacy and reduced side effects of TCM ingredients while discussing the challenges of its clinical application.

This study reported that in animal studies of androgenetic alopecia, a biodegradable microneedle patch releasing glutamic acid promoted hair regeneration more effectively than daily minoxidil, with higher hair follicle counts and less frequent dosing, showing the potential for clinical application.

This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.

This review discusses the design strategies and applications of long-acting polymeric microneedles, noting their potential to improve patient compliance and reduce side effects in chronic disease management, but reports no new experimental results.

This review highlights recent advancements in microneedle technology, noting its ability to enhance transdermal drug delivery, biosensing, cancer treatment, and skin disease repair, while emphasizing its potential for improving patient compliance and reducing side effects.

This review highlights the promising potential of 3D printing for creating microneedles with precise customization and improved performance compared to traditional micromolding, emphasizing applications in personalized medical devices and advancements in biomedical fields.

This study found that bioactive extracts from goat placenta, particularly when delivered via dissolving microneedles, enhanced fibroblast proliferation and skin regeneration without being toxic to skin cells, suggesting a promising dermal application for improving skin health.

This study explores the use of bioinspired 3D printed hollow microneedles, which may offer improved delivery of anti-wrinkle formulations, and reviews the current landscape and challenges of existing wrinkle treatments and microneedle technology.

This review discusses the potential of microneedles in cancer diagnosis and treatment, highlighting advances and ongoing clinical trials, but reports no new results; it emphasizes the minimally invasive nature of this technology.

This review discusses recent advancements in responsive-hydrogel dressings for diabetic wound healing, highlighting their design, responsiveness, and degradation behavior, and evaluating their potential advantages and limitations in clinical applications.

This review highlights the potential of microneedles as a pediatric-friendly method for delivering proteins, vaccines, and diagnostics transdermally, noting their ability to penetrate the skin's barrier and suggesting future applications in other parts of the body.

This study developed a hydrogel microneedle system combining ginseng-derived exosomes and biomimetic nanoparticles to address oxidative stress, inflammation, and melanocyte deficiency in vitiligo, showing significant repigmentation in mice within 3 weeks by enhancing melanocyte protection and keratinocyte proliferation.