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Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Taxane chemotherapy can cause skin, hair, and nail side effects, which are often under-reported and can affect patient quality of life.

Hair follicles may soon be used more for targeted and systemic drug delivery.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Over one-third of women experience hair loss, with female-pattern hair loss being most common, and treatments include minoxidil and possibly hair transplantation.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Different PIN proteins affect plant root hair growth by changing how auxin is transported.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Postinflammatory hyperpigmentation causes dark skin patches and needs personalized treatment.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Oral retinoids are effective for various skin conditions but have side effects and should not be used during pregnancy.

Chemotherapy often causes temporary hair loss, which is distressing and needs better treatment and support.

Male pattern hair loss is genetic and influenced by hormones, with treatments like minoxidil and surgery available.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Voriconazole can cause serious side effects, especially in long-term use.

Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.