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This study found that prolonged Nrf2 activation in mouse keratinocytes led to enlarged sebaceous glands, hair loss, and cysts, suggesting a role for Nrf2 in conditions like MADISH.

This study found that activating CB1 receptor signaling in human hair follicles increased stem cell proliferation while reducing differentiated cell survival, suggesting CB1's role as a survival stimulus for epithelial stem cells.

This study demonstrates that YAP and TAZ are essential for initiating basal and squamous cell carcinomas in mice, and suggests targeting these pathways could be beneficial for treating skin cancers.

This review discusses recent advances in how proinflammatory cytokines affect epidermal stem cell function during skin wound healing and introduces potential therapies targeting these cells and cytokines.

This study found that using 3D dermal papilla spheroid models enhances extracellular matrix production and hair follicle marker expression, providing insights into hair follicle biology and potential for drug screening.

This review explores the infundibulum's role and importance in skin diseases and emphasizes the need for further research into its biology and potential therapeutic targeting, but it presents no new findings.

This review discusses how inflammation influences hair follicle stem cell activities like wound healing and follicle cycling and suggests a potential link between inflammation, stem cell activation, and programmed cell death.

This review summarizes the characteristics of the peri-malignant melanoma stroma, indicating its potential role in early dermal metastatic migration and increased metastasis risk.

This study found that Si Jun Zi Tang may have anti-aging effects in mice, linked to inhibition of the PI3K-AKT and P38 MAPK signaling pathways.

This study found that ingenol mebutate treatment led to gene expression changes in actinic keratoses, with complete lesion clearance in 40% of patients and identified genetic markers potentially predicting treatment response.

This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.

Generalized glucocorticoid resistance causes hormone imbalances and varied symptoms due to gene mutations.

In this study, researchers used patient-derived organoids to model metastasis in colorectal cancer and discovered that cancer cells temporarily switch to a wound-healing program, orchestrated by reduced EZH2 activity and YAP signaling, before spreading to new organs.

This research highlights selenium's critical roles in various biological processes and underscores the potential health impacts of both its deficiency and excess, including increased mortality risk, poor immune function, and neurological issues.

This review reports that the human amniotic membrane has promising regenerative, anti-inflammatory, and antimicrobial properties, suggesting its potential for innovative clinical applications in dermatology, such as wound healing and psoriasis treatment, as well as aesthetic uses like skin rejuvenation and hair regeneration.

This study examined the molecular communication in psoriasis cells, highlighting unique immune cell interactions and identifying new features of the hair follicle cell-psoriasis axis. It suggests the potential for targeted therapies at the single-cell level to improve psoriasis treatment.

This study found that AP-2α and AP-2β transcription factors are crucial for maintaining adult skin homeostasis, with their inactivation in keratinocytes leading to impaired differentiation, hair abnormalities, and inflammation, highlighting their key regulatory roles.

This study found that TNC + fibroblasts are crucial in neuro-immune interactions in various skin diseases, particularly inflammation and tumors, by engaging extensively with immune cells and overexpressing inflammatory genes, suggesting their significant role in skin abnormalities.

This pilot study suggests that a new preparation of platelet-rich plasma gel may improve symptoms and tissue regeneration in patients with en coup de sabre scleroderma, though further trials are needed to clarify its role.

The document explains various skin conditions and their treatments.

Some treatments can improve skin's defense against damage, but overuse may cause other skin problems.

This study explores the correlation between sirtuins' expression, histone deacetylation, and redox status in young and old monozygotic twins to understand their role in age-related mechanisms.

This study found that Nrf2 activation protected keratinocytes from UVB damage but also caused thickening, inflammation, and cysts, limiting its therapeutic potential for skin protection.

This study suggests a potential link between proteasome function and nucleotide excision repair in animal models with defects in the NER pathway, with implications for ageing.

This study reported that high cholesterol levels were linked to increased prostate cancer risk, while selenium supplementation affected gene expression, suggesting nutritional and clinical factors might influence prostate cancer risk and biology.

This study introduced the Lichen Planus Activity and Damage Index (LiPADI), which effectively assesses the severity and progression of lichen planus, aligning well with other clinical indicators.

This review discusses Graham-Little Piccardi-Lasseur syndrome, a rare dermatosis with limited treatment options, emphasizing the importance of early diagnosis through physical exam and dermoscopy, but reports no new results.

In this study, solid lipid microparticles loaded with lidocaine hydrochloride were developed to effectively deliver pain relief and antimicrobial benefits for wound management, demonstrated by testing with bioengineered skin substitutes and showing effectiveness against common wound-infecting bacteria.

The researchers reported that the facial Psoriasis Log-based Area and Severity Index (fPLASI) more reliably and sensitively captured clinical improvement in facial psoriasis than the existing facial Psoriasis Area and Severity Index (fPASI).

In this case report, a rare instance of Graham–Little–Piccardi–Lassueur syndrome coexisting with linear lichen planus was identified in a 35-year-old male, highlighting the condition's rarity in males, with dermoscopy aiding diagnosis through distinctive scalp and trunk lesion features.