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The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Researchers created a new mouse model for studying Citrullinemia Type I and similar conditions, showing symptoms and treatment responses like those in humans.

Minoxidil improves blood flow and vessel flexibility, potentially helping with vascular stiffness.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Finasteride and minoxidil together promote hair growth better than either alone.

Dutasteride makes alcohol less sedating and may lead to less drinking in men.

Ziziphus jujuba Mills may have health benefits, but more research is needed to confirm its safety and effectiveness.

People with Seasonal Affective Disorder have different brain activity in certain areas when resting.

Loose anagen hair syndrome is caused by structural abnormalities in the hair follicle's inner root sheath.

Late pregnancy helps repair brain damage in rats due to the GABAergic system.

Human hair keratin fibers have a detailed nano-scale structure that changes with different conditions.

The document concludes that hair transplantation is recommended for those not helped by medical treatments, but warns that high-density transplants may lower hair survival rates.

New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.

Safflower has been used in traditional medicine for centuries and shows promise in treating heart, brain, and inflammatory conditions, but more research is needed to ensure its safety.

Researchers created a skin treatment that could effectively deliver medication into hair follicles.

Researchers created a 3D hydrogel that mimics human hair follicles, which may help with hair loss treatments.

Sonidegib and vismodegib are similarly effective for advanced basal cell carcinoma, but sonidegib might have a slightly better safety profile.

Nonhead hair transplantation is effective for patients with limited head donor hair, but more research is needed.

Human hair has a new region with ordered filaments and the cuticle contains β-keratin sheets.

Finasteride can cause sexual problems and depression in young men.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

Minoxidil-coated microbubbles with sonication effectively enhance hair growth.

Finasteride cream helps hair growth with less side effects.

Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

An 81-year-old woman's severe male hormone symptoms were caused by an ovarian tumor, which was treated with surgery.