1 citations
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April 2023 in “African Scientific Reports” This review summarizes the biological process of melanogenesis and evaluates natural skin-whitening treatments based on their mechanisms affecting melanin production, aiming to inform on the effects and awareness of skin-bleaching creams.
January 2015 in “Zhongguo haiyang yaowu” This study found that collagen oligopeptides from puffer skin may reduce skin melanin and increase hydroxyproline content in guinea pigs, suggesting potential skin whitening and anti-aging effects.
December 2025 in “Scientific Reports” In this laboratory study, α-mangostin was found to significantly reduce melanin content and downregulate pigmentation-related genes in cultured skin and B16F10 cells, suggesting potential application as a natural whitening agent in sunscreen development.
10 citations
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January 2018 in “Functional Foods in Health and Disease” This study found that berry extracts, especially black raspberry extract, may have anti-aging effects due to their high antioxidant activities.
July 2000 in “International Society of Hair Restoration Surgery” This review highlights the significant impact of finasteride on the approach to androgenetic alopecia and hair transplantation and reports no new clinical results.
46 citations
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October 2025 in “Journal of Nanobiotechnology” This review examines the potential of plant-derived exosome-like nanovesicles in dermatology, highlighting their bioactive properties and discussing challenges to their clinical application, but does not provide new clinical results.
1 citations
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February 2025 in “Journal of Biomedical Research & Environmental Sciences” This review explores the diverse health benefits and pharmacological properties of mushrooms, highlighting their potential use in cosmetics for antioxidant, anti-aging, and anti-hair loss effects due to their bioactive compounds.
1 citations
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January 2018 in “Methods in molecular biology” This research describes methods to activate melanocyte stem cells during hair follicle regeneration and to isolate melanocytes from neonatal mouse skin, with the aim of studying melanogenesis for potential clinical applications.
March 2025 in “Asian Journal of Beauty and Cosmetology” This study found that microspicule cosmetics with low-molecular-weight peptide complexes significantly improved skin whitening, pore condition, and skin barrier function over four weeks compared to a non-microspicule formulation.
This review explores the extraction, characterization, and skin cosmetic effects of phenolic compounds and pigments from marine macroalgae, highlighting their documented benefits for skin health, such as whitening, moisturizing, photoprotection, and anti-aging effects, without adverse health impacts.
March 2009 in “International Society of Hair Restoration Surgery” This article reviews dermatopathology perspectives on diagnosing hair loss conditions and reports no new clinical findings.
13 citations
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August 2019 in “Journal of Ethnopharmacology” This study assessed 11 plants from French Polynesia for their potential development as sustainable natural cosmetics, particularly anti-aging and hair care products, based on their traditional uses and preliminary screening results.
112 citations
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May 2019 in “Pharmacological Research” This review discusses the isolation, structure, and bioactivity of lignans and neolignans from 2016 to mid-2018, reporting no new clinical results but highlighting their potential protective properties against diseases such as cancer and neurodegeneration.
101 citations
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October 2016 in “Nanomedicine: Nanotechnology, Biology and Medicine” This review reports on the dual aspect of fullerene in skincare, highlighting its beneficial antioxidant properties as well as potential toxicity and skin cell reactions, while identifying areas for future research.
73 citations
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July 2016 in “Cosmetics” This review discusses the use of mushrooms and their bioactive compounds in cosmeceuticals and nutricosmetics and reports no new clinical findings, highlighting potential areas for future research and development.
36 citations
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March 2014 in “Biomaterials” This study found that the 11R-No. 10 peptide, delivered transdermally, significantly inhibited melanogenesis and produced a whitening effect in a UV-induced sun-tanning guinea pig model without cytotoxicity.
33 citations
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January 2015 in “Journal of Ginseng Research” This study found that ginsenoside Rg3 significantly inhibited melanogenesis in human melanocytes and B16F10 cells by activating the ERK pathway, suggesting potential as a skin-whitening agent.
27 citations
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June 2015 in “Revista Brasileira de Farmacognosia” This review discusses the traditional uses, pharmacology, clinical applications, and toxicology of Carthami flos but reports no new clinical results, aiming to inform further research on its medicinal potential.
![[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs](/images/assets/4eb017dc-711d-4926-bcd0-c3b8f48e3a99/small/19974.jpg)
26 citations
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July 2007 in “Biochemical Pharmacology” This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.
18 citations
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February 2023 in “Plants” This study found that PES1CMU-defatted rice bran (DFRB) showed effective skin whitening and anti-aging properties comparable to standard treatments in cell models, suggesting its potential use in dermatocosmetics.
15 citations
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October 2012 in “InTech eBooks” Niosomes are a promising and effective way to deliver drugs through the skin.
12 citations
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May 2023 in “Molecules” This study identified seven potential enzyme inhibitors from a Polygonum cuspidatum extract using ultrafiltration combined with high-performance liquid chromatography. These compounds showed inhibitory activity against tyrosinase, α-glucosidase, and xanthine oxidase, with most discovered in this extract for the first time.
9 citations
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November 2022 in “Applied sciences” This review explores marine algae-derived phenolic compounds and their potential cosmeceutical benefits, but reports no new clinical results.
8 citations
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August 2015 in “Journal of dermatological science” This study observed that the topical skin-whitening agent rhododendrol induced skin depigmentation in approximately 16,000 consumers, linked to melanocyte cytotoxicity and immune reactions.
5 citations
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January 2017 in “Elsevier eBooks” This review focuses on the roles of amino acids, peptides, and proteins in cosmetics, highlighting their importance in skin health and their potential for development in personal care products due to their unique properties and biocompatibility.
3 citations
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May 2020 in “Acta pharmaceutica” The researchers reported that protocatechuic acid reduced melanin synthesis and enhanced antioxidant activity in cultured human hair follicle melanocytes, indicating potential for skin whitening applications.
2 citations
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April 2024 in “AIDS Research and Therapy” This case highlights the importance of considering syphilis testing for patients with unusual symptoms like hair loss and hypopigmentation, emphasizing the diagnostic and management challenges in resource-limited settings.
2 citations
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May 2021 in “Journal of pharmaceutical and biomedical analysis” This study utilized a UHPLC-HRMS method to identify eight active pharmaceutical ingredients, such as ketoconazole and minoxidil, in 26 out of 100 analyzed cosmetic products.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review highlights that herbal cosmetics, incorporating modern technologies and traditional knowledge, offer various biological benefits like antioxidant and anti-aging properties. The authors emphasize the need for further clinical validation and standardized manufacturing processes to ensure their long-term safety and effectiveness.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review reports that herbal cosmetics offer diverse biological benefits, including antioxidant, antibacterial, and moisturizing effects, enhanced by advanced formulation methods, while emphasizing the need for more clinical validation and standardized practices to ensure long-term safety and efficacy.