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This chapter reviews the potential of adipose-derived stem cells for skin aging and hair loss treatments but reports no new experimental results; the authors highlight these stem cells as a promising regenerative resource.

In this study, the researchers developed a new protocol using human-induced pluripotent stem cells to efficiently create skin hair follicle organoids, which may aid in optimizing hair follicle growth and exploring treatments for alopecia.

This review discusses the application of mesenchymal stem cells and their secretory factors for skin and hair regeneration and reports no clinical results; the authors highlight the progress and call for practical applications.

This study observed that in aged mouse skin, there was an increase in IL-17-expressing T helper cells, γδ T cells, and innate lymphoid cells, and blocking IL-17 signaling reduced skin inflammation and delayed age-related changes, suggesting it as a potential target to mitigate skin aging.

This study describes a system for generating hair follicles from dissociated cells in mice, suggesting that successful development requires a foundational epithelial platform.

This review highlights the potential of marine-derived nutraceuticals for treating skin and hair disorders, focusing on Viviscal, a supplement shown to be safe and effective in enhancing hair growth by improving cellular function and strengthening hair.

This narrative review highlights the potential of autologous adipose mesenchymal stem cell-derived exosomes (AMSCs-Exos) in anti-skin aging, noting their superior biocompatibility and manufacturing advantages while stressing the need for standardized production protocols to overcome existing application challenges.

This study found that bioelectric and biochemical signaling mechanisms coordinate collective cell movement during chicken feather bud morphogenesis, suggesting a potential new angle for research in skin development and wound healing.

This research presents a comprehensive workflow for producing EMA-compliant autologous keratinocyte-based therapies for wound healing and explores miRNA-mediated regulations in human keratinocytes and adipose-derived mesenchymal stem cells.

This study found that the proteins GDNF, NTN, GFRα-1, GFRα-2, and c-Ret are differentially expressed during various stages of the human hair follicle cycle, with potential implications for hair biology.

This study identified the osteopontin-derived peptide, FOL-005, as a potential inhibitor of unwanted human hair growth by promoting catagen development without reducing stem cell numbers or showing toxicity.

In this study, researchers developed a chemical cocktail and suspension culture method to transform human dermal fibroblasts into dermal papilla-like cells capable of inducing hair follicle formation in vitro and in vivo.

This study found that adipose-derived stem cell-conditioned media improved skin flap survival following ischemia/reperfusion injury in mice by increasing cell proliferation and the number of hair follicles, mediated by IL-6.

This review highlights the potential of exosomes as a novel therapeutic approach for skin diseases and aging, due to their stability, transportability, and ability to carry various bioactive compounds to target cells.

This study suggests that skin-derived precursors from Sox2(+) hair follicle dermal cells have the potential to function as dermal stem cells, supporting hair morphogenesis, dermal maintenance, and wound-healing.

This study demonstrated that cultured epidermal stem cells and skin-derived precursors can regenerate functional hair follicles and sebaceous glands in both mice and adult humans, suggesting potential for bioengineered skin substitutes.

In this study, researchers found that WNT activation influenced FGF expression in human scalp-derived fibroblasts, with mouse model results showing FGF9 increased hair follicle number and diameter, while FGF7 reduced diameter.

In this study, using stirred-suspension bioreactors to expand dermal stem cells resulted in larger numbers, but had reduced efficiency in forming hair follicle structures compared to static culture conditions.

In this study, researchers developed an axolotl skin-derived extracellular matrix scaffold that enhanced wound healing in mice by promoting skin regeneration and reducing fibrosis, offering potential as a regenerative biomaterial for clinical use.

This study reports that a single intradermal injection of autologous adipose-derived stem cells improved visible aging signs such as wrinkles and pore size on facial skin for over a year in eight patients, with in vitro data suggesting muscle involvement in the rejuvenation process.

This review discusses the roles and characteristics of skin stem cells, their niches, and signaling pathways in skin maintenance, aging, and cancer, highlighting their potential in therapeutic applications but presenting no new clinical findings.

This review examines the potential of plant-derived exosome-like nanovesicles in dermatology, highlighting their bioactive properties and discussing challenges to their clinical application, but does not provide new clinical results.

This study found that intradermal administration of adipose-derived stem cell–conditioned medium significantly increased hair density and dermal thickness, suggesting potential regenerative effects on both hair follicles and the interfollicular scalp in patients with alopecia.

This review suggests that the umbilical cord-derived mesenchymal stem cell secretome presents a promising approach for skin regeneration and wound healing due to its multiple therapeutic properties, highlighting its potential over traditional treatments for conditions like chronic wounds and alopecia.

In this source, recent single-cell RNA-sequencing advances reveal significant transcriptional heterogeneity among skin fibroblasts, and the discussion focuses on the distinct subtypes' roles in skin homeostasis, repair, and their evolution in fibrotic diseases like keloid scars and cancer.

A new method was developed to create better skin models for healing and reconstruction.

This study found that human iPSC-derived melanocytes from vitiligo patients successfully integrated into mouse hair follicles and epidermis, demonstrating potential for personalized therapy for depigmentation.

This animal study found that dermal papilla cells in hair follicles of chimeric mice can originate from various fibroblasts in the skin, challenging assumptions about their specific lineage.

This study created a detailed spatial atlas of healthy human skin and basal cell carcinoma, revealing a potential hair follicle origin for basal cell carcinoma and expansion of certain mesenchymal cell populations.

This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.