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Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

Applying a specific inhibitor lightens skin and hair color.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

Men are more likely to get infectious skin diseases, while women are more prone to autoimmune and pigment-related skin conditions, influenced by biological and environmental factors.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.

Using neurohormones to control keratin can lead to new skin disease treatments.

Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.

Using defensins to activate stem cells may improve skin aging signs without causing inflammation.

Honokiol helps protect skin from damage and aging caused by cigarette smoke.

Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.

Non-invasive methods show promise for diagnosing skin diseases like psoriasis and lupus but need more research for regular use.

Hair follicles are essential for skin health, aiding in hair growth, wound healing, and immune function.

The microenvironment, especially mechanical forces, plays a crucial role in hair growth and could lead to new treatments for hair loss.

Chicken feather gene mutation helps understand human hair disorders.

Estrogen and androgenic hair increase melanoma risk, especially in European-ancestry individuals.

Skin structure complexity and variability are crucial for assessing skin toxicity in safety tests.

Topical treatments can deliver active molecules to skin stem cells, potentially helping treat skin and hair disorders, including skin cancers and hair loss.

Lymphatic vessels are important for skin repair and could affect skin disease treatments.

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

Dermal stem cells help regenerate hair follicles and heal skin wounds.

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

SCF and ET-1 together significantly increase skin pigmentation and melanin production.

Mohs micrographic surgery is effective for early-stage non-melanoma skin cancers on the lips, with basal cell carcinoma more common on the upper cutaneous lip and squamous cell carcinoma more common on the lower vermilion lip.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Certain microRNAs are linked to various skin diseases and could be used to diagnose and treat these conditions.