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This study concluded that Trilayer Dissolving Microneedles show promise in enhancing Minoxidil delivery for treating alopecia areata by improving its bioavailability and reducing side effects.

This review highlights recent developments in nanovesicular carriers for enhancing molecule delivery into and across the skin, focusing on the design and evolution of phospholipid and non-phospholipid systems used in cosmetics and treating various skin conditions.

This study found that pretreating mouse skin with microneedles significantly enhanced the hair growth inhibitory effect of eflornithine cream, likely by improving its skin permeation.

This study investigated a nanostructured system using PS-b-PAA diblock copolymer for incorporating the hydrophobic photosensitizer ClAlPc, finding it effective in causing cellular damage in Caco-2 cells under light while demonstrating no cytotoxicity without light, suggesting its potential use in photodynamic therapy.

This review highlights recent advancements in using niosomes as nanocarriers for improved delivery and sustained release of active cosmetic compounds, discussing their properties, applications, and future potential in cosmetic chemistry.

This study found that the cyanoacrylate biopsy method could effectively evaluate drug distribution in hair follicles, suggesting its potential utility for assessing topically applied chemicals targeting hair follicles.

This review discusses ethosomal delivery systems for topical drugs, highlighting their potential to improve treatment efficacy for conditions like herpes labialis and male pattern baldness, and reports no new clinical results.

This study found that a dutasteride-loaded liposomal system significantly increased skin permeability and drug deposition in mouse skin compared to other formulations, suggesting improved localized treatment potential for androgenetic alopecia.

This study explored chitosan-based dissolving microneedle arrays loaded with Agave tequilana root extract, finding that extract concentration influenced microneedle geometry and bioactivity, maintaining antioxidant and enzyme inhibitory effects while reducing collagenase inhibition, particularly in the 0.25% formulation.

This paper discusses ethosomal drug delivery systems, highlighting their improved ability to enhance skin penetration and increase therapeutic effectiveness in treatments like acyclovir for herpes labialis and minoxidil for androgenic alopecia compared to standard formulations.

This study reports that ethosomal formulations, such as ethosomal acyclovir and minoxidil, improved therapeutic effectiveness by enhancing skin permeation, leading to faster healing of herpes labialis lesions and increased skin absorption compared to standard formulations.

This review discusses the expanding understanding of TRPV3's role in pain and skin pathology, while highlighting the need for further pharmacological research to fully resolve its functions.

This study found that a minoxidil foamable emu oil emulsion significantly promoted hair growth in animals compared to a marketed 5% minoxidil solution, showing increased hair follicles in the anagenic phase.

This study found that ex vivo, the skin permeability of caffeine increased with formulations using natural caffeine from coffee extract, particularly when combined with 2.5% Transcutol P, compared to synthetic caffeine formulations.

This study found that a topical gel containing Minoxidil and Tofacitinib citrate showed promise for treating alopecia areata, with formulation F5 demonstrating effective drug release and stability in evaluations.

This study found that Spironolactone-loaded ethosomal gels provided superior skin permeation and deposition compared to niosomal gels in rabbit skin, suggesting that ethosomal gels could be a promising formulation for further clinical studies on treating androgenic alopecia.

This study found that retinoic acid and a retinol complex formulation showed different permeation and compound localization in a skin equivalent model, with unique lipid changes observed with only the retinol formulation.

This review examined the role of the ion channel TRPV3 in warmth sensation and skin physiology, discussing controversies around its direct contribution to temperature perception, its involvement in skin health, and its potential as a therapeutic target for skin diseases.

This review explores the development and cosmeceutical applications of microneedles for skin treatment, without reporting new clinical results, emphasizing safety and public perception as key factors for commercialization.

This study found that surface modified nanoparticles showed increased skin permeation and improvement in allergic contact dermatitis, independent of the follicular pathway.

This study observed that chitosan-decorated PS404-b-PAA63 nanoparticles may enhance skin retention and reduce permeation flux of finasteride, suggesting potential for improved transdermal delivery.

This review discusses iontophoresis, low-frequency ultrasound, and microneedles for enhancing topical drug delivery in dermatological treatments and reports no clinical results; it emphasizes their mechanisms and potential uses.

This study found that a transdermal delivery system using 3% azone and P407 gel may enhance the skin permeation of doxazosin and finasteride for treating benign prostatic hyperplasia.

This study found that increasing the proportion of ethanol in minoxidil formulations improved skin penetration in both in vitro and in vivo tests on mice.

This review discusses recent advances in skin penetration mechanisms, specifically focusing on the enhanced understanding of the follicular pathway and its implications for transdermal therapies, immune system targeting, and nanoparticle safety.

In this study, a novel liposomal formulation combining caffeine and cafestol significantly enhanced their penetration into human skin layers, with formulation F9 doubling caffeine and greatly increasing cafestol levels in the dermis, suggesting potential for improved topical delivery.

This article proposes that androgenic alopecia might be an evolutionary mechanism for reducing prostate cancer risk by enhancing UV absorption, rather than being a risk factor.

The conclusion is that proper communication about the realistic effects of hair loss and skin aging treatments can improve dermatologists' credibility.

This review discusses the use of terpenes and invasomes as permeation enhancers for transdermal drug delivery, focusing on their potential applications in pharmaceutical formulations, but it reports no new experimental results.

This study found that finasteride delivered through dissolving microneedles enhanced skin drug permeation compared to films, suggesting potential for improved androgenetic alopecia treatment with fewer side effects.