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The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Biotin supplementation during isotretinoin treatment for acne may help maintain skin hydration and improve hair growth.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Wild African goats have genetic adaptations for surviving harsh desert conditions.

Adipokines affect skin health and could be targeted for treating skin diseases.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Some skin diseases may indicate a higher risk of metabolic syndrome and related health issues.

South Asian women with PCOS are more likely to have metabolic issues and central obesity, and simple measures like waist size and blood pressure can help identify these risks early.

Teens with PCOS and a mom with PCOS have higher insulin resistance and lower adiponectin levels, which could signal early metabolic problems.

Adult female acne requires a comprehensive treatment approach, including medical options and lifestyle changes, with attention to psychological well-being.

Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.

Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

Auto-portraits help evaluate scalp hair.

Biotin supplements are unnecessary for most people but may help with certain conditions like biotin deficiency, brittle nails, and some hair loss.

Isotretinoin therapy for acne can cause many reversible side effects, mainly mild skin conditions, and patient understanding of these effects can improve treatment adherence.

Certain gene variations might help protect against insulin resistance and glucose intolerance in people with Polycystic Ovary Syndrome.

Taking DHEA for a year is generally safe for postmenopausal women but may cause acne and more facial hair without improving metabolism or aging.

Two women with very high androgen levels had only slight skin issues, one due to a non-classical adrenal disorder and the other due to an adrenal tumor.

Early balding in young Indian men may indicate a higher risk of metabolic syndrome and potential heart disease.

Hormone imbalance is linked to Hidradenitis Suppurativa, a skin condition, and treatments like anti-androgenic therapy and metformin can help. It's also suggested to check patients for insulin resistance and Polycystic Ovary Syndrome.

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.

Early hair loss may be linked to metabolic syndrome.

The combined Myo-inositol and D-chiro-inositol treatment improved weight, hormone levels, and skin conditions in women with PCOS.

Patients with alopecia areata have higher oxidative stress and lower antioxidant levels.

People with lichen planus are more likely to have dyslipidemia, especially higher triglyceride levels.

Women with PCOS and higher BMI, especially those with morbid obesity, are at greater risk for depression.

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

Testosterone therapy can help improve sexual function, mood, and bone density in women with low androgen levels, but more research is needed on long-term safety.