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GlossarySkin Sensitivity (Skin Irritation)

condition where skin reacts easily to external stimuli

Skin Sensitivity, also known as Sensitive Skin or Dermal Sensitivity, refers to a condition where the skin reacts more easily to external stimuli such as chemicals, fragrances, or environmental factors. This can result in symptoms like redness, itching, burning, or dryness. It is often due to a weakened skin barrier or heightened nerve endings, making the skin more prone to irritation and discomfort.

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Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

17 citations, June 2017 in “Journal of pharmaceutical sciences”

Researchers developed a nanomedicine for acne treatment that delivers medication with less irritation and is non-irritating for oily skin.

research Panax Notoginseng Saponins Loaded Water-In-Oil Microemulsion for Alopecia Therapy with Panthenol as Cosurfactant to Reduce Skin Irritation

August 2024 in “International Journal of Pharmaceutics”

The treatment promotes hair growth, improves hair density, and reduces skin irritation.

research Ion Pairs of Risedronate for Transdermal Delivery and Enhanced Permeation Rate on Hairless Mouse Skin

34 citations, July 2011 in “International journal of pharmaceutics”

Ion-paired risedronate significantly increases skin penetration without irritation compared to risedronate alone.

research The Early Changes in Mouse Skin Following Topical Application of a Range of Middle Distillate Oil Products

19 citations, July 1993 in “Journal of Applied Toxicology”

Different oil products cause varying levels of skin irritation in mice, which could potentially lead to tumors.

research Acute Dermal and Ocular Irritation Testing of Rice Bran Supercritical CO2 Extract (RB-SCE) and 0.5% RB-SCE Essence Product

2 citations, March 2015 in “Toxicology and Environmental Health Sciences”

Rice bran extract caused moderate skin irritation but no eye irritation, while a diluted essence was not irritating to skin and only slightly to guinea pigs.

research Irritation And Hair Growth Activity Test Of Male S-D Mice: Effect Of Gel Containing Apigenin And Celery Juice

1 citations, January 2015

The gel with apigenin and celery juice promotes hair growth without causing skin irritation.

research Hair, Nail, and Skin Changes During COVID-19 Era

November 2021 in “Egyptian Journal of Medical Microbiology”

COVID-19 protective measures led to skin irritation, hair loss, and brittle nails; using skin-friendly products and a healthy diet is recommended.

research Co-Drug Strategy for Promoting Skin Targeting and Minimizing the Transdermal Diffusion of Hydroquinone and Tranexamic Acid

21 citations, September 2013 in “Current medicinal chemistry”

HAC and BAC improve skin targeting and reduce diffusion without causing irritation.

research Strontium: A Potent and Selective Inhibitor of Sensory Irritation and Topical Anti-inflammatory

May 2003 in “Hair transplant forum international”

Strontium can effectively reduce skin irritation and inflammation.

Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum Copticum Seeds

research Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum Copticum Seeds

August 2018

Ajwain seed extract improved skin healing and hair growth in a mouse skin irritation model.

research In Vitro Evaluation of Skin Distribution and Human Dermal Papilla Cells Proliferation for Minoxidil 5% Topical Lotion Hydrogel

July 2022 in “Journal of Investigative Dermatology”

The new minoxidil hydrogel is a promising alternative for hair loss treatment, with similar effectiveness and less skin irritation.

research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

25 citations, February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking SCD1 in the skin with XEN103 shrinks sebaceous glands in mice.

research Liposomes with an Ethanol Fraction as an Application for Drug Delivery

24 citations, November 2018 in “International Journal of Molecular Sciences”

Ethosomes improve drug delivery through the skin but may have side effects like irritation.

research Contact Dermatitis in Reaction to 2% Topical Minoxidil Solution

23 citations, April 1991 in “Journal of The American Academy of Dermatology”

Minoxidil solution can cause skin irritation and allergies in some users.

research Allergens of Permanent Hair Dyes Induce Epidermal Damage, Skin Barrier Loss, and IL-1 Alpha Increase in Epidermal In Vitro Model

12 citations, December 2017 in “Food and chemical toxicology”

Permanent hair dye mixtures can irritate and damage the skin.

research Preparation and In Vivo Evaluation of Lecithin-Based Microparticles for Topical Delivery of Minoxidil

12 citations, August 2017 in “Archives of Pharmacal Research”

Lecithin-based microparticles can deliver minoxidil for hair growth effectively with less skin irritation.

research Irritation Test And Hair Growth Activity In White Rats: Effects Of Apigenin Gel And Celery Herb Juice (Apium Graveolens L.)

9 citations, May 2015 in “Media Penelitian dan Pengembangan Kesehatan”

The gel with apigenin and celery juice improved hair growth in rats without causing skin irritation.

research The Effect of Different Preoperative Depilation Methods on the Healing of Wounded Skin in Mice

5 citations, February 2022 in “Animals”

Sodium sulfide slows wound healing, while electric shaving is the safest for preoperative hair removal.

research New Hair Growth Cream Formulation with Cocoa Pod Peel (Theobroma Cacao L.)

1 citations, March 2022 in “The Scientific World Journal”

The cream made from cocoa pod peel can promote hair growth but may cause skin irritation.

Cardamonin-Loaded Liposomal Formulation for Improving Percutaneous Penetration and Follicular Delivery for Androgenetic Alopecia

research Cardamonin-Loaded Liposomal Formulation for Improving Percutaneous Penetration and Follicular Delivery for Androgenetic Alopecia

February 2024 in “Drug Delivery and Translational Research”

A new liposomal formulation improves drug delivery and hair growth for treating hair loss without causing skin irritation.

research Development and Characterization of Thiolated Cyclodextrin-Based Nanoparticles for Topical Delivery of Minoxidil

October 2023

Thiolated cyclodextrin-based nanoparticles effectively deliver Minoxidil for scalp treatment without causing skin irritation.

research Nano Gold Color Transparent Shampoo Bar

July 2019 in “Iconic Research And Engineering Journals”

The shampoo bar with Aloe vera and cinnamon oil improved hair health and protected against fungi without causing skin irritation.

research The Preparation of High Minoxidil Loaded Transfersomes and Its Gel for Effective Topical Treatment of Alopecia

April 2023 in “Journal of Drug Delivery Science and Technology”

The new minoxidil gel improves hair growth and reduces skin irritation.

research Topical Delivery of Atraric Acid Derived From Stereocaulon Japonicum With Enhanced Skin Permeation and Hair Regrowth Activity for Androgenic Alopecia

January 2023 in “Pharmaceutics”

AA–TF#15 significantly promotes hair regrowth and could be an effective treatment for androgenic alopecia.

research A Homozygous Single T Deletion Found in the GGCX Gene with PXE-Like Phenotypes

September 2016 in “Journal of Dermatological Science”

A gene mutation worsens skin irritation in mice due to a lack of certain fats.

research Increasing the Percutaneous Absorption and Follicular Penetration of Retinal by Topical Application of Proretinal Nanoparticles

14 citations, March 2019 in “European journal of pharmaceutics and biopharmaceutics”

Proretinal nanoparticles improve skin absorption and reduce irritation of topical retinoids.

research Contact Dermatitis to Minoxidil

34 citations, September 1985 in “Contact Dermatitis”

Minoxidil can cause skin irritation like eczema and rash in some users.

research Safety Evaluation of Topical Valproate Application

6 citations, June 2013 in “Toxicological Research”

Topical Valproate is safe for human skin and unlikely to cause irritation.

research Severe Marking-Nut Dermatitis

4 citations, November 2012 in “Dermatitis”

A man got severe skin irritation after using marking nut sap for hair loss.

research Regulatory News Related to Cosmetic Products

4 citations, March 2007 in “Annales de Dermatologie et de Vénéréologie”

Hair care products can cause skin irritation and allergies due to certain chemicals.