research Short-Chain Fatty Acids from Cutibacterium Acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes
Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.
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research Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies
Skin abnormalities can indicate immunodeficiency due to shared origins with the immune system.
research The Atypical Itch That Rashes: Disseminated And Recurrent Infundibulofolliculitis (DRIF) In An Atopic African American Male
Consider DRIF and perform skin biopsies for persistent papular rashes.
research Over- And Ectopic-Expression Of FoxN1 At Early Life Adversely Influences Lymphopoiesis
Early over-expression of FoxN1 harms immune and skin development.
research Local Inflammation Exacerbates Cutaneous Manifestations in a Murine Autoimmune Pemphigus Model
Local inflammation worsens autoimmune skin conditions by increasing antibody buildup.
research Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice
Increasing Treg cells in the skin does not cure hair loss from alopecia areata in mice.
research Helminth TGF-β Mimic, TGM, Increases Leukocyte Migration and Activation While Also Enhancing Cutaneous Wound Healing and Tissue Regeneration
A parasite molecule can speed up skin healing and reduce scarring.
research Dupilumab: A Review of Present Indications and Off-Label Uses
Dupilumab is being tested for many new skin, respiratory, and gastrointestinal conditions.
research Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease
Hidradenitis suppurativa might be a type of autoinflammatory skin disease.
research Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases
A protein called lfTSLP is important in causing allergic and other skin diseases and could be a target for treatment.
research T Cell–Mediated Acute Localized Exanthematous Pustulosis Caused by Finasteride
Finasteride caused a rare skin rash in a man, which improved after stopping the medication.
research Severe Pustular Lesions Induced by Topical Immunotherapy with Squaric Acid Dibutylester for Alopecia Totalis
Squaric acid dibutylester can cause severe skin reactions in people with allergies.
research Allergen Of The Month: Witch Hazel
Witch hazel can help protect skin and may fight colon cancer cells.
research The L412F Variant of Toll-Like Receptor 3 Is Associated with Cutaneous Candidiasis, Increased Susceptibility to Cytomegalovirus, and Autoimmunity
The L412F variant of TLR3 is linked to skin infections, more viral infections, and autoimmune issues.
research Acute Generalized Exanthematous Pustulosis Induced by Hydroxychloroquine Prescribed for COVID-19
A patient developed a severe skin reaction and died after taking hydroxychloroquine for COVID-19.
research The Important Role of Leptin in Modulating the Risk of Dermatological Diseases
Leptin, a hormone from fat cells, affects immune responses and can influence skin diseases and hair growth.
research Topical Application of Dehydroxymethylepoxyquinomicin Improves Allergic Inflammation via NF-κB Inhibition
A new cream, DHMEQ, reduces allergic skin inflammation effectively.
research Pathomechanisms of Immune-Mediated Alopecia
The study concluded that immune cells attacking hair follicles cause hair loss in alopecia, with genetics and environment also playing a role, and highlighted the potential of certain treatments.
research Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration
Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.
research Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease
Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.
research Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia
Exosomes from fat-derived stem cells can potentially improve hair growth and could be a new treatment for immune-related hair loss.
research Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues
Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.
research Local Heroes or Villains: Tissue-Resident Memory T Cells in Human Health and Disease
Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.
research An Essential Role for RXRα in the Development of Th2 Responses
RXRα is crucial for proper immune response and links diet to immune function.
research Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy–Like Autoimmune Disease
AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.
research Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in Alzheimer's Disease and Rosacea
Melatonin could be an effective treatment for Alzheimer's Disease and rosacea.
research Skin: Basic Structure and Function
The skin is a complex barrier that protects the body, regulates temperature, and helps with immune responses.
research Anticytokine Therapy, Particularly Anti-IFN-γ, in Th1-Mediated Autoimmune Diseases
Blocking interferon-gamma might help treat various autoimmune diseases.
research A Rapidly Progressive Case of Skin and Soft Tissues Necrosis in a COVID-19 Positive Patient
COVID-19 may lead to severe skin necrosis without clear underlying causes, as seen in a diabetic patient who required leg amputation.
research Skin and Glucocorticoids: Effects of Local Skin Glucocorticoid Impairment on Skin Homeostasis
Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.