147 citations
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November 2020 in “International Journal of Molecular Sciences” This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.
43 citations
,
April 1996 in “Journal of Investigative Dermatology”
38 citations
,
September 2014 in “Cell and Tissue Research” This review explores the infundibulum's role and importance in skin diseases and emphasizes the need for further research into its biology and potential therapeutic targeting, but it presents no new findings.
August 2021 in “Oxford University Press eBooks” This chapter discusses various skin functions and structures involved in protection, immune response, and homeostasis, but it reports no new research findings.
4 citations
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November 2014 The skin protects the body, regulates temperature, senses touch, and makes vitamin D.
1 citations
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January 2012 in “Elsevier eBooks” The document concludes that the skin is a complex organ providing protection, sensation, and healing, with challenges in treating conditions like itchiness.
36 citations
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January 2014 in “Elsevier eBooks” This narrative review discusses the structure and functions of the skin, focusing on its barrier role, self-repair, thermoregulation, and immune functions, and reports no new experimental results.
4 citations
,
December 2020 in “Tissue Barriers” This review explores the immunological aspects of epidermal differentiation in loricrin knockout mice, offering insights into keratinization and potential intrinsic factors affecting immune function, but provides no new clinical findings.
56 citations
,
March 2015 in “Journal of Investigative Dermatology” Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.
45 citations
,
October 2008 in “Cytokine & Growth Factor Reviews” This review discusses the role of activin signaling in hair follicle formation, hair growth cycling, and skin healing, but presents no new clinical findings.
56 citations
,
November 2022 in “Biomolecules” This review explores the role of macrophage subsets in adult cutaneous wound healing and emphasizes their potential for therapeutic targeting, but reports no new experimental results.
2 citations
,
September 2025 in “International Journal of Nanomedicine” This review discusses the roles of extracellular vesicles in skin health and disease and reports no clinical results; the authors highlight potential therapeutic uses and call for more research.
5 citations
,
February 2022 in “International Journal of Molecular Sciences” This review discusses the roles of distinct immune cell types in skin wound healing, highlighting findings from animal studies, but provides no new clinical results.
1 citations
,
September 2025 in “Frontiers in Immunology” This study found that FRβ knockout mice exhibited autoimmune symptoms and slower tumor growth compared to wild type mice, suggesting that the FRβ receptor may play a role in regulating immune responses in tumors and autoimmune conditions.
June 2026 in “Frontiers in Immunology” This review highlights the potential for JAK inhibitors to effectively treat inflammatory and autoimmune skin diseases by targeting the JAK-STAT signaling pathway, advocating for an integrated approach to enhance targeted therapy.
November 2025 in “The Journal of Immunology” This study identified specific genes upregulated in skin γδ T cells involved in alopecia areata, with findings suggesting these cells contribute to disease pathogenesis through inflammatory and Th1 response mechanisms in mouse and possibly human skin.
April 2018 in “Journal of Investigative Dermatology” In this study, TRPV3G568V mice exhibited periodic hair loss and immune cell infiltration in the dermis, without affecting hair follicle stem cell fate, suggesting a focus on dermal immune cells for future research.
November 2022 in “Journal of Investigative Dermatology” This study provides evidence that ILC1-like cells can induce alopecia areata in previously healthy human hair follicles, challenging the view that it is solely an autoantigen-dependent autoimmune disease.
October 2025 in “Journal of Investigative Dermatology” This review highlights the critical role of iron in skin functions and suggests potential dermatologic therapies targeting the iron-skin axis.
June 2024 in “Journal of Allergy and Clinical Immunology” In this study, thymic stromal lymphopoietin (TSLP) induced IL-4/IL-13 from T cells, prompting sebum secretion and adipose loss, suggesting IL-4/IL-13 may affect skin barrier function in atopic dermatitis.
127 citations
,
January 2015 in “Journal of Biological Rhythms” This review discusses the role of the circadian clock in skin functions such as cell proliferation and UV protection and reports no new results; the authors note its potential in studying immune regulation and seasonal behaviors.
24 citations
,
December 2018 in “Inflammation and Regeneration” This review discusses the roles of various PLA2 enzymes in skin health and disease, highlighting potential pathways for future diagnosis and therapy, but it reports no new clinical results.
In this research, geography was found to explain more variation in the human skin microbiome than skin type, while host genetics contributed unique microbial structures, highlighting their role in skin microbiome ecology through extensive genomic and metagenomic analyses in a diverse international cohort.
January 2014 in “eScholarship (California Digital Library)” In this study, researchers observed that TLR3 and scavenger receptors play key roles in skin barrier repair following UVB damage, contributing to our understanding of cellular responses to skin injury.
122 citations
,
April 2020 in “American Journal Of Pathology” This review discusses the multiple factors contributing to skin aging, including cellular changes and environmental influences, and highlights its recognition as a disease with significant implications beyond cosmetic concerns, without reporting new research results.
March 2026 in “Nature Communications” In this study, researchers conducted a large genome-wide association meta-analysis and found 30 significant genetic loci linked to the risk of dermatophytosis, shedding light on the roles of keratin biology, skin barrier defects, immune dysfunction, and obesity in the disease.
January 2026 in “International Journal of Innovative Technologies in Social Science” This narrative review explores existing evidence on zinc's impact in certain immune-related, gastrointestinal, dermatological, and metabolic disorders, considering clinical and observational studies to assess zinc supplementation's clinical relevance.
152 citations
,
December 2007 in “Gender Medicine” This review discusses recent advances in understanding gender differences in skin and their implications for dermatologic diseases, but it reports no new experimental results; ongoing research is necessary for translating these insights into clinical practice.
37 citations
,
October 2021 in “Journal of Clinical Investigation” This study suggests that inflammation in the skin can exacerbate intestinal inflammation in inflammatory bowel diseases by activating fibroblasts in the colon through hyaluronan fragments released during skin inflammation.
5 citations
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January 2021 in “Animal Production Science” In this study, 467 genes with differential expression between fine-wool and coarse-wool sheep, particularly those related to lipid metabolism, were identified as potentially influencing wool fibre diameter.