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This study demonstrates that encapsulating cell-free fat extract in a gelatin methacrylate hydrogel enhances flap repair by sustaining angiogenesis, reducing oxidative stress, and offering favorable biocompatibility in a murine skin flap model, thereby advancing potential clinical flap necrosis treatments.

This study found that dermal adipocytes contribute to efficient skin repair by releasing fatty acids that recruit macrophages and transforming into myofibroblasts that aid wound healing.

This study found that feeding mice a high-fat diet with fish oil leads to hair loss through a mechanism involving omega-3 fatty acids and TNF-α signaling, with epidermal fatty acid binding protein playing a key role.

This review discusses the unique features of dermal white adipose tissue, its interaction with hair follicles, and its role in skin physiology, reporting no new experimental findings.

This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.

This article reviews technical aspects of using autologous fat transfer for facial rejuvenation and examines existing evidence for stem cell and platelet-rich plasma therapies in aesthetic practice, reporting no new results.

This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.

This study investigated dermal fibroblasts in mouse skin using single-cell RNA sequencing and identified signaling pathways that influence adipogenesis, finding that IL-1-NF-κB promotes, while WNT-β-catenin inhibits, the adipogenic potential of these cells, with implications for wound healing and scar formation.

This study identified a distinct CD49fhigh mesenchymal stem cell subpopulation in the dermis that supports hair follicle development and maintenance via Notch signaling activation.

This study found that UVB irradiation alters skin stem cell niches leading to signs of photoaging, which may be reversed by adipose-derived stem cells through BMP4 pathway modulation and niche remodeling.

This review highlights the therapeutic potential of various skin stem cell populations for tissue repair and regenerative medicine, but presents no new clinical findings.

This review discusses mesenchymal stem cells' role in tissue regeneration and skin anti-aging, highlighting their migration to damaged sites and secretome effects, but reports no new clinical results.

This review discusses the potential of mesenchymal stem cell therapies for treating various skin diseases, including vitiligo, alopecia, and epidermolysis bullosa, but reports no new results.

In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.

This study reports that a single intradermal injection of autologous adipose-derived stem cells improved visible aging signs such as wrinkles and pore size on facial skin for over a year in eight patients, with in vitro data suggesting muscle involvement in the rejuvenation process.

This review presents evidence supporting the potential of adipose-derived stem cell secretome as a promising cell-free therapy for skin repair, emphasizing its application in wound healing, alopecia, skin rejuvenation, and inflammatory skin diseases.

This study found that transplanting adipose tissue into the rat dorsum supported long-term skin expansion by enhancing thickness, vascularization, and cell proliferation, with adipose-derived cells actively contributing to skin regeneration and growth factor expression.

This study found that intradermal injections of autologous cell-free fat extract significantly improved the condition of postinflammatory hyperpigmentation patients, with high patient satisfaction and minimal adverse effects.

This study found that Pdgfα signaling is crucial for maintaining dermal adipose tissue in mice by initiating dermal adipocyte stem cell proliferation, with implications for age-related skin defects.

This study found that overexpression of erythropoietin disrupted hair growth in mice by affecting dermal fat lipogenesis and lipolysis, leading to poor hair follicle development and truncal alopecia.

This study found that melatonin treatment increased epidermal thickness, subcutaneous fat, and dermal-related factors in postmenopausal rats, suggesting benefits for skin structure after menopause.

This review discusses how aging affects hair follicle stem cells and their environment, contributing to hair loss, and explores strategies to promote hair regrowth, but reports no new results.

This study found that skin bacteria promote regeneration in wound-induced hair follicle neogenesis, suggesting a role for IL-1β signaling and challenging the belief that infection inhibits healing.

This review discusses the roles and mechanisms of tissue-resident regulatory T cells in immune regulation and tissue homeostasis, but reports no new experimental results.

This study found that a dietary change in common marmosets significantly reduced in vitro erythrocyte haemolysis, improved skin lesions, and promoted complete fur regrowth, possibly due to increased vitamin E levels.

This review discusses dermal white adipose tissue's roles in skin immunity, highlighting its antimicrobial function and interactions with other immune cells, but reports no new clinical results.

In this study, Alox15 knockout mice exhibited disrupted skin integrity and increased inflammation, suggesting that Alox15-mediated resolvin D2 production is crucial for maintaining skin homeostasis by suppressing inflammation.

This study found that the BP-3 extract from Boesenbergia rotunda, rich in panduratin A, demonstrated strong anti-adipogenesis and lipolysis effects on preadipocyte cells at non-toxic concentrations, and when formulated into a serum reduced thigh circumference and improved skin firmness in a human trial.

This study found that in mice, dermal adipocytes initiate inflammation and aid repair after skin injury by releasing lipids, suggesting a role in managing inflammatory diseases and impaired wound healing.

This research abstract provides no results, focusing on the equal contributions of the authors in the field of molecular, cellular, and developmental biology from Yale University.