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    Glossary Skin Equivalents

    lab-grown models mimicking human skin for research and testing

    Skin equivalents are lab-grown models of human skin created using a combination of cells and biomaterials. These constructs mimic the structure and function of natural skin, making them valuable for research, drug testing, and studying skin diseases without the need for human or animal subjects.

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    1. An improved and rapid method to construct skin equivalents from human hair follicles and fibroblasts Experimental dermatology · 2001 · 48 citations
    2. 3D Printing of Skin Equivalents with Hair Follicle Structures and Epidermal‐Papillary‐Dermal Layers Using Gelatin/Hyaluronic Acid Hydrogels Chemistry - an Asian journal · 2022 · 18 citations
    3. Skin Tissue-Engineering Constructs and Stem Cells Application for the Skin Equivalents Creation (Review) Sovremennye tehnologii v medicine · 2017 · 11 citations
    4. Skin equivalent assay: An optimized method for testing for hair growth reconstitution capacity of epidermal and dermal cells Experimental Dermatology · 2019 · 8 citations
    5. Restructuring skin equivalents with human hair follicle orscs and fibroblasts Journal of Plastic Reconstructive & Aesthetic Surgery · 2007
    6. Endogenous human skin equivalent promotes in vitro morphogenesis of follicle-like structures Biomaterials · 2016 · 36 citations
    7. Skin equivalent containing collagen-human hair keratin matrice for formation of neodermis Jiepouxue zazhi · 2003
    8. Development of a novel in vitro strategy to understand the impact of shaving on skin health: combining tape strip exfoliation and human skin equivalent technology Frontiers in Medicine · 2023
    9. The importance of the neuro‐immuno‐cutaneous system on human skin equivalent design Cell Proliferation · 2019 · 73 citations
    10. Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three‐dimensional skin equivalent model <i>in vitro</i>: implications for regenerative therapy of canine epidermis Veterinary dermatology · 2013 · 11 citations
    11. Self Organized Skin Equivalent by Epithelial and Fibroblast Cells on Polycaprolactone Electrospun Mat with Porous Fibers Advances in tissue engineering & regenerative medicine · 2017 · 4 citations
    12. 3D Bioprinting Skin Equivalents: A Methodological Perspective on Human Keratinocyte and Fibroblast Models for Wound Repair and Regeneration Wound Repair and Regeneration · 2025 · 3 citations
    13. Keratinocytes-hair follicle bulge stem cells-fibroblasts co-cultures on a tri-layer skin equivalent derived from gelatin/PEG methacrylate nanofibers Journal of Biomaterials Science Polymer Edition · 2020 · 11 citations
    14. The Model of an Ischemic Non-Healing Wound: Regeneration after Transplantation of a Living Skin Equivalent Sovremennye tehnologii v medicine · 2023
    15. Sheep vibrissa dermal papillae induce hair follicle formation in heterotypic skin equivalents British Journal of Dermatology · 1994 · 21 citations
    16. Engineering a 3D wounded skin equivalent to study early inflammatory and regenerative responses in vitro Frontiers in Bioengineering and Biotechnology · 2025 · 1 citations
    17. Characterization of a new tissue-engineered human skin equivalent with hair In Vitro Cellular & Developmental Biology - Animal · 1999 · 221 citations
    18. 710 Use of mass spectrometry imaging and a full thickness 3D skin equivalent for evaluation of percutaneous absorption Journal of Investigative Dermatology · 2017
    19. Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion Lab on a Chip · 2013 · 208 citations
    20. Enhanced Differentiation Potential of Pigmented Human Epidermal Equivalents 2026
    21. Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction International Journal of Molecular Sciences · 2021 · 54 citations
    22. MicroRNAs in skin tissue engineering Advanced drug delivery reviews · 2015 · 39 citations
    23. Recent advances in understanding the role of the skin microbiome in the treatment of atopic dermatitis Experimental Dermatology · 2023 · 18 citations
    24. 331 Characterisation of interfollicular stem cells and early TA cells during the transition from infant to child skin Journal of Investigative Dermatology · 2021
    25. In Vitro Skin Models for Pigmentary Disorders: From Reconstructed Tissues to Skin-on-a-Chip Platforms Regenerative Biomaterials · 2026
    26. Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging Ageing Research Reviews · 2026
    27. Tissue-scale tensional homeostasis in skin regulates structure and physiological function Communications Biology · 2020 · 47 citations
    28. A perfusable vascularized full-thickness skin model for potential topical and systemic applications Biofabrication · 2021 · 21 citations
    29. Remarks on the Hormonal Background of the Male Equivalent of Polycystic Ovary Syndrome Prague medical report · 2021 · 1 citations
    30. In-vitro permeation of drugs into porcine hair follicles: is it quantitatively equivalent to permeation into human hair follicles? Journal of Pharmacy and Pharmacology · 2008 · 19 citations