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    Glossary Skin Differentiation

    process where skin cells mature into specialized types

    Skin differentiation refers to the process by which skin cells develop and mature into their specialized forms and functions. This involves the transformation of undifferentiated stem cells into various types of skin cells, such as keratinocytes, melanocytes, and fibroblasts, each playing a specific role in maintaining the skin's structure and function. This process is crucial for skin regeneration, wound healing, and maintaining the skin's protective barrier.

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    Research 30 of 1000+

    1. C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin PloS one · 2010 · 48 citations
    2. Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13 -Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation 2015 · 16 citations
    3. Autophagy-Mediated Cellular Remodeling during Terminal Differentiation of Keratinocytes in the Epidermis and Skin Appendages Cells · 2024 · 7 citations
    4. Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin Genes & Development · 2001 · 555 citations
    5. 169 TEDAR, a skin-specific long non-coding RNA, orchestrates the late epidermal differentiation program in the human epidermis Journal of Investigative Dermatology · 2025
    6. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin Proceedings of the National Academy of Sciences · 2001 · 201 citations
    7. Wnt-10b secreted from lymphocytes promotes differentiation of skin epithelial cells Biochemical and Biophysical Research Communications · 2006 · 28 citations
    8. The involvement of Elf5 in regulating keratinocyte proliferation and differentiation processes in skin PLoS ONE · 2025
    9. The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity Stem cell biology and regenerative medicine · 2018
    10. Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours Development · 2002 · 297 citations
    11. Skin tumors with matrical differentiation: lessons from hair keratins, beta‐catenin and PHLDA‐1 expression Journal of Cutaneous Pathology · 2014 · 47 citations
    12. Growth Differentiation Factor 11 (GDF11)/Transforming Growth Factor - β (TGF - β)/Mesenchymal Stem Cells (MSCs) Balance: A Complicated Partnership in Skin Rejuvenation Journal of Embryology & Stem Cell Research · 2019 · 1 citations
    13. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    14. Regulation of adipocyte dedifferentiation at the skin wound edge bioRxiv (Cold Spring Harbor Laboratory) · 2023
    15. Lymphotoxin-β regulates periderm differentiation during embryonic skin development Human Molecular Genetics · 2007 · 12 citations
    16. CLK1 and its Effects on Skin Stem Cell Differentiation Digital WPI · 2010 · 1 citations
    17. Mechanotransductive Differentiation of Hair Follicle Stem Cells Derived from Aged Eyelid Skin into Corneal Endothelial-Like Cells Stem Cell Reviews and Reports · 2021 · 9 citations
    18. Single-cell analysis of 2,3,7,8-tetrachlorodibenzo- <i>p</i> -dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes <i>Ahr</i> -dependent seboatrophy with elevated expression of infundibular <i>Blimp1</i> bioRxiv (Cold Spring Harbor Laboratory) · 2026
    19. Proliferation and Differentiation of Human Hair Follicle Stem Cells on Chitosan-Skin Engineered Template in Vitro International Journal on Advanced Science, Engineering and Information Technology · 2017
    20. Wnt-10b promotes differentiation of skin epithelial cells in vitro Biochemical and Biophysical Research Communications · 2006 · 36 citations
    21. 177 The Striatin-Interacting Phosphatase And Kinases complex is important for skin epidermal differentiation and barrier formation 2022
    22. The Mixed Lineage Kinase Leucine-Zipper Protein Kinase Exhibits a Differentiation-Associated Localization in Normal Human Skin and Induces Keratinocyte Differentiation upon Overexpression Journal of Investigative Dermatology · 2000 · 17 citations
    23. Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects against Malignant Progression Cell Reports · 2013 · 15 citations
    24. Novel Quinazoline Derivative Induces Differentiation of Keratinocytes and Enhances Skin Barrier Functions against Th2 Cytokine-Mediated Signaling Molecules · 2023 · 2 citations
    25. LB1256 TRIV-509, a dual inhibitor of KLK5 and KLK7, rapidly improves barrier integrity and markers of epidermal differentiation in atopic dermatitis skin explants Journal of Investigative Dermatology · 2025
    26. Differentiation of HaCaT skin cells in culture and their potential for studying atopic dermatitis Skemman · 2023
    27. 1330 Flexible fate determination ensures robust differentiation in the skin hair follicle Journal of Investigative Dermatology · 2018
    28. Mutant Cx43 in Skin Differentiation and Disease 2011
    29. Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium Mechanisms of Development · 2004 · 56 citations
    30. Neutrophil gelatinase‐associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin Experimental dermatology · 2002 · 96 citations